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10.5483/BMBRep.2017.50.2.199 http://scihub22266oqcxt.onion/10.5483/BMBRep.2017.50.2.199 C5342869!5342869!27916025     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMB+Rep 2017 ; 50 (2): 71-8 Nephropedia Template TP {{tp|p=27916025|t=2017. The role of extracellular biophysical cues in modulating the Hippo-YAP pathway |pdf=|usr=}}{{27916025}} gab.com Text The role of extracellular biophysical cues in modulating the Hippo-YAP pathway JO: BMB Rep http://www.kidney.de/pget.php?&tw=1&pmid=27916025 #FOAvip The Hippo signaling pathway plays an essential role in adult-tissue homeostasis and organ-size control. In Drosophila and vertebrates, it consists of a highly conserved kinase cascade, which involves MST and Lats that negatively regulate the activity of the downstream transcription coactivators, YAP and TAZ. By interacting with TEADs and other transcription factors, they mediate both proliferative and antiapoptotic gene expression and thus regulate tissue repair and regeneration. Dysregulation or mutation of the Hippo pathway is linked to tumorigenesis and cancer development. Recent studies have uncovered multiple upstream inputs, including cell density, mechanical stress, G-protein-coupled receptor (GPCR) signaling, and nutrients, that modulate Hippo pathway activity. This review focuses on the role of the Hippo pathway as effector of these biophysical cues and its potential implications in tissue homeostasis and cancer. Twit Text FOAVip The role of extracellular biophysical cues in modulating the Hippo-YAP pathway ????BMB Rep http://www.kidney.de/pget.php?&tw=1&pmid=27916025 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27916025 #FOAvip English Wikipedia <ref>{{Cite pmid|27916025}}</ref> The role of extracellular biophysical cues in modulating the Hippo-YAP pathway #MMPMID27916025 Mo JS BMB Rep 2017[]; 50 (2): 71-8 PMID27916025show ga The Hippo signaling pathway plays an essential role in adult-tissue homeostasis and organ-size control. In Drosophila and vertebrates, it consists of a highly conserved kinase cascade, which involves MST and Lats that negatively regulate the activity of the downstream transcription coactivators, YAP and TAZ. By interacting with TEADs and other transcription factors, they mediate both proliferative and antiapoptotic gene expression and thus regulate tissue repair and regeneration. Dysregulation or mutation of the Hippo pathway is linked to tumorigenesis and cancer development. Recent studies have uncovered multiple upstream inputs, including cell density, mechanical stress, G-protein-coupled receptor (GPCR) signaling, and nutrients, that modulate Hippo pathway activity. This review focuses on the role of the Hippo pathway as effector of these biophysical cues and its potential implications in tissue homeostasis and cancer. äThe role of extracellular biophysical cues in modulating the Hippo-YAP(epmc).pdf DeepDyve Pubget Overpricing