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10.18632/oncotarget.12709 http://scihub22266oqcxt.onion/10.18632/oncotarget.12709 C5342804!5342804!27764770     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2016 ; 7 (46): 76159-68 Nephropedia Template TP {{tp|p=27764770|t=2016. Visualization of early prostatic adenocarcinoma as a stem cell disease |pdf=|usr=}}{{27764770}} gab.com Text Visualization of early prostatic adenocarcinoma as a stem cell disease JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27764770 #FOAvip Prostate Cancer represents the second leading cause of cancer death among men in the United States, and the third leading cause of cancer death among men in Europe. We have previously shown that cells possessing Cancer Stem Cell (CSC) characteristics can be grown from human PrCa tissue harvested at the time of prostatectomy. However, the cellular origin of these CSCs was not previously known. In most cases, simple hematoxylin and eosin (H&E) stained sections are sufficient to make a definitive diagnosis of prostatic adenocarcinoma (PrCa) in needle biopsy samples. We utilized six different antibodies specific for stem cell antigens to examine paraffin sections of PrCa taken at the time of needle-biopsy diagnosis. These antisera were specific for CD44, CD133, ALDH7A1, LGR-5, Oct-4 and NANOG. We demonstrate specific staining of tumor cells with all six antisera specific for stem cell antigens. Some of these antibodies also react with cells of hyperplastic glands, but the patterns of reactivity differ from those of malignant glands. These findings demonstrate that at the time of diagnosis, PrCa consists of cells exhibiting properties of CSCs and consistent with the possibility that PrCa is a stem cell disease. Twit Text FOAVip Visualization of early prostatic adenocarcinoma as a stem cell disease ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27764770 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27764770 #FOAvip English Wikipedia <ref>{{Cite pmid|27764770}}</ref> Visualization of early prostatic adenocarcinoma as a stem cell disease #MMPMID27764770 Jiang MY; Lee TL; Hao SS; Mahooti S; Baird SM; Donoghue DJ; Haas M Oncotarget 2016[Nov]; 7 (46): 76159-68 PMID27764770show ga Prostate Cancer represents the second leading cause of cancer death among men in the United States, and the third leading cause of cancer death among men in Europe. We have previously shown that cells possessing Cancer Stem Cell (CSC) characteristics can be grown from human PrCa tissue harvested at the time of prostatectomy. However, the cellular origin of these CSCs was not previously known. In most cases, simple hematoxylin and eosin (H&E) stained sections are sufficient to make a definitive diagnosis of prostatic adenocarcinoma (PrCa) in needle biopsy samples. We utilized six different antibodies specific for stem cell antigens to examine paraffin sections of PrCa taken at the time of needle-biopsy diagnosis. These antisera were specific for CD44, CD133, ALDH7A1, LGR-5, Oct-4 and NANOG. We demonstrate specific staining of tumor cells with all six antisera specific for stem cell antigens. Some of these antibodies also react with cells of hyperplastic glands, but the patterns of reactivity differ from those of malignant glands. These findings demonstrate that at the time of diagnosis, PrCa consists of cells exhibiting properties of CSCs and consistent with the possibility that PrCa is a stem cell disease. äVisualization of early prostatic adenocarcinoma as a stem cell disease(epmc).pdf DeepDyve Pubget Overpricing