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10.18632/oncotarget.11013 http://scihub22266oqcxt.onion/10.18632/oncotarget.11013 C5342700!5342700 !27494892     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27494892 &cmd=llinks): Failed to open stream: HTTP request failed! 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Sirtuin 1 stimulates the proliferation and the expression of glycolysis genes in pancreatic neoplastic lesions |pdf=|usr=}}{{27494892 }} gab.com Text Sirtuin 1 stimulates the proliferation and the expression of glycolysis genes in pancreatic neoplastic lesions JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27494892 #FOAvip Metabolic reprogramming is a feature of neoplasia and tumor growth. Sirtuin 1 (SIRT1) is a lysine deacetylase of multiple targets including metabolic regulators such as p53. SIRT1 regulates metaplasia in the pancreas. Nevertheless, it is unclear if SIRT1 affects the development of neoplastic lesions and whether metabolic gene expression is altered.To assess neoplastic lesion development, mice with a pancreas-specific loss of Sirt1 (Pdx1-Cre;Sirt1-lox) were bred into a KrasG12D mutant background (KC) that predisposes to the development of pancreatic intra-epithelial neoplasia (PanIN) and ductal adenocarcinoma (PDAC). Similar grade PanIN lesions developed in KC and KC;Sirt1-lox mice but specifically early mucinous PanINs occupied 40% less area in the KC;Sirt1-lox line, attributed to reduced proliferation. This was accompanied by reduced expression of proteins in the glycolysis pathway, such as GLUT1 and GAPDH.The stimulatory effect of SIRT1 on proliferation and glycolysis gene expression was confirmed in a human PDAC cell line. In resected PDAC samples, higher proliferation and expression of glycolysis genes correlated with poor patient survival. SIRT1 expression per se was not prognostic but low expression of Cell Cycle and Apoptosis Regulator 2 (CCAR2), a reported SIRT1 inhibitor, corresponded to poor patient survival.These findings open perspectives for novel targeted therapies in pancreatic cancer. Twit Text FOAVip Sirtuin 1 stimulates the proliferation and the expression of glycolysis genes in pancreatic neoplastic lesions ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27494892 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27494892 #FOAvip English Wikipedia <ref>{{Cite pmid|27494892 }}</ref> Sirtuin 1 stimulates the proliferation and the expression of glycolysis genes in pancreatic neoplastic lesions #MMPMID27494892 Pinho AV ; Mawson A ; Gill A ; Arshi M ; Warmerdam M ; Giry-Laterriere M ; Eling N ; Lie T ; Kuster E ; Camargo S ; Biankin AV ; Wu J ; Rooman I Oncotarget 2016[Nov]; 7 (46 ): 74768-74778 PMID27494892 show ga Metabolic reprogramming is a feature of neoplasia and tumor growth. Sirtuin 1 (SIRT1) is a lysine deacetylase of multiple targets including metabolic regulators such as p53. SIRT1 regulates metaplasia in the pancreas. Nevertheless, it is unclear if SIRT1 affects the development of neoplastic lesions and whether metabolic gene expression is altered.To assess neoplastic lesion development, mice with a pancreas-specific loss of Sirt1 (Pdx1-Cre;Sirt1-lox) were bred into a KrasG12D mutant background (KC) that predisposes to the development of pancreatic intra-epithelial neoplasia (PanIN) and ductal adenocarcinoma (PDAC). Similar grade PanIN lesions developed in KC and KC;Sirt1-lox mice but specifically early mucinous PanINs occupied 40% less area in the KC;Sirt1-lox line, attributed to reduced proliferation. This was accompanied by reduced expression of proteins in the glycolysis pathway, such as GLUT1 and GAPDH.The stimulatory effect of SIRT1 on proliferation and glycolysis gene expression was confirmed in a human PDAC cell line. In resected PDAC samples, higher proliferation and expression of glycolysis genes correlated with poor patient survival. SIRT1 expression per se was not prognostic but low expression of Cell Cycle and Apoptosis Regulator 2 (CCAR2), a reported SIRT1 inhibitor, corresponded to poor patient survival.These findings open perspectives for novel targeted therapies in pancreatic cancer. |*Gene Expression Regulation, Neoplastic [MESH] |Animals [MESH] |Carcinoma in Situ [MESH] |Carcinoma, Pancreatic Ductal/genetics/metabolism/pathology [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation [MESH] |Cell Transformation, Neoplastic/genetics/metabolism [MESH] |Disease Models, Animal [MESH] |Glucose/*metabolism [MESH] |Glycolysis/genetics [MESH] |Humans [MESH] |Mice [MESH] |Mice, Transgenic [MESH] |Pancreatic Neoplasms/*genetics/*metabolism/mortality/pathology [MESH] |Prognosis [MESH]Sirtuin 1 stimulates the proliferation and the expression of glycolysi(epmc).pdf DeepDyve Pubget Overpricing