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10.18632/oncotarget.12958 http://scihub22266oqcxt.onion/10.18632/oncotarget.12958 C5342686!5342686 !27801673     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27801673 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2016 ; 7 (46 ): 74557-74568 Nephropedia Template TP {{tp|p=27801673 |t=2016. Beauveria attenuates asthma by inhibiting inflammatory response and inducing lymphocytic cell apoptosis |pdf=|usr=}}{{27801673 }} gab.com Text Beauveria attenuates asthma by inhibiting inflammatory response and inducing lymphocytic cell apoptosis JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27801673 #FOAvip The present study aimed to investigate the role of beauveria (BEA) in asthma. We investigated the cytotoxic effect of BEA on the proliferation of inflammatory cells and secretion of inflammatory mediators both in-vitro and in-vivo. In in-vitro studies, BEA inhibited lymphocytic cell proliferation and the proliferation of lymphocytic cells induced by Phorbol-12-myristate-13-acetate (PMA). We used ELISA to test the effects of BEA on the secretion of inflammatory factors including tumor necrosis factor-alpha (TNF-?), interleukin-12 (IL-12) and interferon-gamma (IFN-?). Flow cytometry was used to evaluate the influence of BEA on cell apoptosis. The effect of BEA on the cell numbers of eosinophils, lymphocytes, macrophages, neutrophils and other cells in mouse bronchoalveolar lavage fluid (BALF) was also evaluated. The expression of apoptosis related molecules Bax, Caspase-3 and Bcl-2 was examined by Western blotting analysis. Our results indicated that BEA played a protective role in asthma. BEA inhibited lymphocytic cell proliferation and secretion of inflammatory mediators. BEA promoted cell apoptosis, stimulated the expression of Bax and Caspase-3 and inhibited Bcl-2 protein expression in a dose-dependent manner. In in-vivo experiments, BEA reduced the cell number of eosinophils, lymphocytes, macrophages, neutrophils and other cells in mouse BALF. BEA inhibited secretion of inflammatory mediators, stimulated expression of Bax and Caspase-3, and inhibited expression of Bcl-2 in mouse lung tissue dose-dependently. All together, our results indicated that BEA could attenuate asthma by inhibiting inflammatory response and induce apoptosis of inflammatory cells. Twit Text FOAVip Beauveria attenuates asthma by inhibiting inflammatory response and inducing lymphocytic cell apoptosis ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27801673 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27801673 #FOAvip English Wikipedia <ref>{{Cite pmid|27801673 }}</ref> Beauveria attenuates asthma by inhibiting inflammatory response and inducing lymphocytic cell apoptosis #MMPMID27801673 Zhang J ; Zhou X ; Zhu J Oncotarget 2016[Nov]; 7 (46 ): 74557-74568 PMID27801673 show ga The present study aimed to investigate the role of beauveria (BEA) in asthma. We investigated the cytotoxic effect of BEA on the proliferation of inflammatory cells and secretion of inflammatory mediators both in-vitro and in-vivo. In in-vitro studies, BEA inhibited lymphocytic cell proliferation and the proliferation of lymphocytic cells induced by Phorbol-12-myristate-13-acetate (PMA). We used ELISA to test the effects of BEA on the secretion of inflammatory factors including tumor necrosis factor-alpha (TNF-?), interleukin-12 (IL-12) and interferon-gamma (IFN-?). Flow cytometry was used to evaluate the influence of BEA on cell apoptosis. The effect of BEA on the cell numbers of eosinophils, lymphocytes, macrophages, neutrophils and other cells in mouse bronchoalveolar lavage fluid (BALF) was also evaluated. The expression of apoptosis related molecules Bax, Caspase-3 and Bcl-2 was examined by Western blotting analysis. Our results indicated that BEA played a protective role in asthma. BEA inhibited lymphocytic cell proliferation and secretion of inflammatory mediators. BEA promoted cell apoptosis, stimulated the expression of Bax and Caspase-3 and inhibited Bcl-2 protein expression in a dose-dependent manner. In in-vivo experiments, BEA reduced the cell number of eosinophils, lymphocytes, macrophages, neutrophils and other cells in mouse BALF. BEA inhibited secretion of inflammatory mediators, stimulated expression of Bax and Caspase-3, and inhibited expression of Bcl-2 in mouse lung tissue dose-dependently. All together, our results indicated that BEA could attenuate asthma by inhibiting inflammatory response and induce apoptosis of inflammatory cells. |*Apoptosis/genetics/immunology [MESH] |*Beauveria [MESH] |Animals [MESH] |Asthma/*etiology/*metabolism [MESH] |Biomarkers [MESH] |Caspase 3/genetics/metabolism [MESH] |Collagen/metabolism [MESH] |Cytokines/metabolism [MESH] |Disease Models, Animal [MESH] |Gene Expression [MESH] |Inflammation Mediators/metabolism [MESH] |Lymphocyte Activation/immunology [MESH] |Lymphocytes/*immunology/*metabolism [MESH] |Mice [MESH] |Mycoses/*complications/microbiology [MESH] |Proto-Oncogene Proteins c-bcl-2/genetics/metabolism [MESH]Beauveria attenuates asthma by inhibiting inflammatory response and in(epmc).pdf DeepDyve Pubget Overpricing