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10.1038/aps.2016.129 http://scihub22266oqcxt.onion/10.1038/aps.2016.129 C5342663!5342663 !28042873     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28042873 &cmd=llinks): Failed to open stream: HTTP request failed! 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A mini-network balance model for evaluating the progression of cardiovascular complications in Goto-Kakizaki rats |pdf=|usr=}}{{28042873 }} gab.com Text A mini-network balance model for evaluating the progression of cardiovascular complications in Goto-Kakizaki rats JO: Acta Pharmacol Sin http://www.kidney.de/pget.php?&tw=1&pmid=28042873 #FOAvip Cardiovascular complications represent a leading cause of mortality in patients with type 2 diabetes mellitus (T2DM). During such complicated progression, subtle variations in the cardiovascular risk (CVR)-related biomarkers have been used to identify cardiovascular disease at the incipient stage. In this study we attempt to integrally characterize the progression of cardiovascular complications and to assess the beneficial effects of metformin combined with salvianolic acid A (Sal A), in Goto-Kakizaki (GK) rats with spontaneous T2DM. The rats were treated with metformin (200 mg·kg(-1)·d(-1), ig) alone or in combination with Sal A (1 mg·kg(-1)·d(-1), ip) at ages from 8 to 22 weeks. During the treatment, the levels of asymmetric dimethylarginine, L-arginine, superoxide dismutase, malondialdehyde, glucose, high density lipoprotein and low density lipoprotein were assessed. Based on alterations in these biomarkers, a mini-network balance model was established using matrixes and vectors. Radar charts were created to visually depict the disruption of CVR-related modules (endothelial function, oxidative stress, glycation and lipid profiles). The description for the progression of cardiovascular disorder was quantitatively represented by u, the dynamic parameter of the model. The modeling results suggested that untreated GK rats tended to have more severe cardiovascular complications than the treatment groups. Metformin monotherapy retarded disease deterioration, whereas the combination treatment ameliorated the disease progression via restoring the balance. The current study, which focused on the balance of the mini-network and interactions among CVR-related modules, proposes a novel method for evaluating the progression of cardiovascular complications in T2DM as well as a more beneficial intervention strategy. Twit Text FOAVip A mini-network balance model for evaluating the progression of cardiovascular complications in Goto-Kakizaki rats ????Acta Pharmacol Sin http://www.kidney.de/pget.php?&tw=1&pmid=28042873 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28042873 #FOAvip English Wikipedia <ref>{{Cite pmid|28042873 }}</ref> A mini-network balance model for evaluating the progression of cardiovascular complications in Goto-Kakizaki rats #MMPMID28042873 Jiang H ; Wang YH ; Wei CX ; Zhang X ; Liu HC ; Liu XQ Acta Pharmacol Sin 2017[Mar]; 38 (3 ): 362-370 PMID28042873 show ga Cardiovascular complications represent a leading cause of mortality in patients with type 2 diabetes mellitus (T2DM). During such complicated progression, subtle variations in the cardiovascular risk (CVR)-related biomarkers have been used to identify cardiovascular disease at the incipient stage. In this study we attempt to integrally characterize the progression of cardiovascular complications and to assess the beneficial effects of metformin combined with salvianolic acid A (Sal A), in Goto-Kakizaki (GK) rats with spontaneous T2DM. The rats were treated with metformin (200 mg·kg(-1)·d(-1), ig) alone or in combination with Sal A (1 mg·kg(-1)·d(-1), ip) at ages from 8 to 22 weeks. During the treatment, the levels of asymmetric dimethylarginine, L-arginine, superoxide dismutase, malondialdehyde, glucose, high density lipoprotein and low density lipoprotein were assessed. Based on alterations in these biomarkers, a mini-network balance model was established using matrixes and vectors. Radar charts were created to visually depict the disruption of CVR-related modules (endothelial function, oxidative stress, glycation and lipid profiles). The description for the progression of cardiovascular disorder was quantitatively represented by u, the dynamic parameter of the model. The modeling results suggested that untreated GK rats tended to have more severe cardiovascular complications than the treatment groups. Metformin monotherapy retarded disease deterioration, whereas the combination treatment ameliorated the disease progression via restoring the balance. The current study, which focused on the balance of the mini-network and interactions among CVR-related modules, proposes a novel method for evaluating the progression of cardiovascular complications in T2DM as well as a more beneficial intervention strategy. |*Models, Biological [MESH] |Alkenes/therapeutic use [MESH] |Animals [MESH] |Cardiovascular Diseases/etiology/*physiopathology/prevention & control [MESH] |Diabetes Complications/*physiopathology/prevention & control [MESH] |Diabetes Mellitus, Type 2/complications/drug therapy/*physiopathology [MESH] |Disease Progression [MESH] |Drug Therapy, Combination [MESH] |Hypoglycemic Agents/therapeutic use [MESH] |Metformin/therapeutic use [MESH] |Polyphenols/therapeutic use [MESH]A mini-network balance model for evaluating the progression of cardiov(epmc).pdf DeepDyve Pubget Overpricing