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10.18632/oncotarget.12160 http://scihub22266oqcxt.onion/10.18632/oncotarget.12160 C5342541!5342541 !27659523     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27659523 &cmd=llinks): Failed to open stream: HTTP request failed! 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Interferon-stimulated gene 15 induces cancer cell death by suppressing the NF-?B signaling pathway |pdf=|usr=}}{{27659523 }} gab.com Text Interferon-stimulated gene 15 induces cancer cell death by suppressing the NF- B signaling pathway JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27659523 #FOAvip Interferon-stimulated gene 15 (ISG15) is an important cytokine that has been reported in carcinogenesis. However, we found that ISG15 and de-ISGylase USP18 were induced by several anti-cancer agents, which was confirmed by both RT-PCR and immunoblotting assays. Further studies demonstrated that ectopic ISG15 and USP18 inhibited proliferation of myeloma, leukemia and cervical cancer cells. More importantly, ISG15 and USP18 induced cancer cell apoptosis. This finding was confirmed in a cervical xenograft model in which cervical cancer growth was suppressed by lentiviral ISG15. In the mechanistic study, ISG15 was found to disrupt the NF-?B signaling pathway by downregulating the expression of IKK? and p65, phosphorylation of p65 and I?B?. Consistent with this finding, ISG15 suppressed the expression of NF-?B recognition element-driving luciferase and decreased the transcription of XIAP and Mcl-1, two typical genes regulated by NF-?B. Therefore, the present study demonstrated that ISG15 induces cancer cell apoptosis by disrupting the NF-?B signaling pathway. This study highlighted a novel role of ISG15 in tumor suppression. Twit Text FOAVip Interferon-stimulated gene 15 induces cancer cell death by suppressing the NF- B signaling pathway ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27659523 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27659523 #FOAvip English Wikipedia <ref>{{Cite pmid|27659523 }}</ref> Interferon-stimulated gene 15 induces cancer cell death by suppressing the NF-?B signaling pathway #MMPMID27659523 Mao H ; Wang M ; Cao B ; Zhou H ; Zhang Z ; Mao X Oncotarget 2016[Oct]; 7 (43 ): 70143-70151 PMID27659523 show ga Interferon-stimulated gene 15 (ISG15) is an important cytokine that has been reported in carcinogenesis. However, we found that ISG15 and de-ISGylase USP18 were induced by several anti-cancer agents, which was confirmed by both RT-PCR and immunoblotting assays. Further studies demonstrated that ectopic ISG15 and USP18 inhibited proliferation of myeloma, leukemia and cervical cancer cells. More importantly, ISG15 and USP18 induced cancer cell apoptosis. This finding was confirmed in a cervical xenograft model in which cervical cancer growth was suppressed by lentiviral ISG15. In the mechanistic study, ISG15 was found to disrupt the NF-?B signaling pathway by downregulating the expression of IKK? and p65, phosphorylation of p65 and I?B?. Consistent with this finding, ISG15 suppressed the expression of NF-?B recognition element-driving luciferase and decreased the transcription of XIAP and Mcl-1, two typical genes regulated by NF-?B. Therefore, the present study demonstrated that ISG15 induces cancer cell apoptosis by disrupting the NF-?B signaling pathway. This study highlighted a novel role of ISG15 in tumor suppression. |*Apoptosis [MESH] |Animals [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation [MESH] |Clioquinol/pharmacology [MESH] |Cytokines/*physiology [MESH] |Endopeptidases/physiology [MESH] |Female [MESH] |Humans [MESH] |Mefloquine/pharmacology [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |NF-kappa B/*physiology [MESH] |Neoplasms/*pathology [MESH] |Signal Transduction/*physiology [MESH] |Tumor Suppressor Proteins/*physiology [MESH] |Ubiquitin Thiolesterase [MESH]Interferon-stimulated gene 15 induces cancer cell death by suppressing(epmc).pdf DeepDyve Pubget Overpricing