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2016 ; 7
(34
): 55368-55376
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Incidence and origin of histologically confirmed liver metastases: an explorative
case-study of 23,154 patients
#MMPMID27421135
de Ridder J
; de Wilt JH
; Simmer F
; Overbeek L
; Lemmens V
; Nagtegaal I
Oncotarget
2016[Aug]; 7
(34
): 55368-55376
PMID27421135
show ga
BACKGROUND: The liver is a common metastatic site for a large variety of primary
tumors. For both patients with known and unknown primary tumors it is important
to understand metastatic patterns to provide tailored therapies. OBJECTIVE: To
perform a nationwide exploration of the origins of histological confirmed liver
metastases. RESULTS: A total of 23,154 patients were identified. The majority of
liver metastases were carcinomas (n=21,400; 92%) of which adenocarcinoma was the
most frequent subtype (n=17,349; 75%). Most common primary tumors in patients
with adenocarcinoma were from colorectal (n=8,004), pancreatic (n=1,755) or
breast origin (n=1,415). In women of 50 years and younger, metastatic
adenocarcinoma originated more frequently from breast cancer, while in women
older than 70 years liver metastases originated more frequently from
gastrointestinal tumors. Liver metastases in men older than 70 years originated
often from squamous cell lung carcinoma. An unknown primary tumor was detected in
4,209 (18%) patients, although tumor type could be determined in 3,855 (92%) of
them. METHODS: Data were collected using the nationwide network and registry of
histo- and cytopathology in the Netherlands (PALGA). All histological confirmed
liver metastases between January 2001 and December 2010 were evaluated for tumor
type, origin of the primary tumor and were correlated with patient
characteristics (age, gender). CONCLUSION: The current study provides an overview
of the origins of liver metastases in a series of 23,154 patients.