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10.18632/oncotarget.10842 http://scihub22266oqcxt.onion/10.18632/oncotarget.10842 C5342401!5342401 !27474170     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27474170 &cmd=llinks): Failed to open stream: HTTP request failed! 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Metformin increases PDH and suppresses HIF-1? under hypoxic conditions and induces cell death in oral squamous cell carcinoma |pdf=|usr=}}{{27474170 }} gab.com Text Metformin increases PDH and suppresses HIF-1 under hypoxic conditions and induces cell death in oral squamous cell carcinoma JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27474170 #FOAvip BACKGROUND: Metformin is a biguanide, belonging to the oral hypoglycemic agents and is a widely used in the treatment of type 2 diabetes. Evidence indicate that Metformin inhibits cell proliferation in several human cancers and inhibits the Warburg phenomenon in tumor cells. RESULTS: Low PDH levels were observed in OSCC, and Metformin promotes an increase in PDH levels in hypoxic conditions. Metformin also reduced HIF-1? mRNA and protein levels. Metformin demonstrated antiproliferative effects, inhibited migration, increased the number of apoptotic cells and increased the transcription of caspase 3. OBJECTIVE: The present study aims to explore the effects of Metformin in hypoxic conditions. Specifically, we focused on pyruvate dehydrogenase (PDH), (hypoxia-inducible factor 1?) HIF-1? levels and the oral squamous cell carcinoma (OSCC) cell phenotype. Additionally, we also investigated a theoretical consequence of Metformin treatment. METHODS: PDH levels in patients with OSCC and oral dysplasia were evaluated. Metformin was administered in vitro to test the effect of Metformin under hypoxic conditions. The results were complemented by Bioinformatics analyses. CONCLUSIONS: In conclusion, our current findings show that Metformin reduces HIF-1? gene expression and increases PDH expression. Metformin inhibits cell proliferation and migration in the OSCC cell line model. Additionally, Metformin enhances the number of apoptotic cells and caspase 3 levels. Interestingly enough, Metformin did not increase the mutant p53 levels under hypoxic conditions. Twit Text FOAVip Metformin increases PDH and suppresses HIF-1 under hypoxic conditions and induces cell death in oral squamous cell carcinoma ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27474170 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27474170 #FOAvip English Wikipedia <ref>{{Cite pmid|27474170 }}</ref> Metformin increases PDH and suppresses HIF-1? under hypoxic conditions and induces cell death in oral squamous cell carcinoma #MMPMID27474170 Guimarães TA ; Farias LC ; Santos ES ; de Carvalho Fraga CA ; Orsini LA ; de Freitas Teles L ; Feltenberger JD ; de Jesus SF ; de Souza MG ; Santos SH ; de Paula AM ; Gomez RS ; Guimarães AL Oncotarget 2016[Aug]; 7 (34 ): 55057-55068 PMID27474170 show ga BACKGROUND: Metformin is a biguanide, belonging to the oral hypoglycemic agents and is a widely used in the treatment of type 2 diabetes. Evidence indicate that Metformin inhibits cell proliferation in several human cancers and inhibits the Warburg phenomenon in tumor cells. RESULTS: Low PDH levels were observed in OSCC, and Metformin promotes an increase in PDH levels in hypoxic conditions. Metformin also reduced HIF-1? mRNA and protein levels. Metformin demonstrated antiproliferative effects, inhibited migration, increased the number of apoptotic cells and increased the transcription of caspase 3. OBJECTIVE: The present study aims to explore the effects of Metformin in hypoxic conditions. Specifically, we focused on pyruvate dehydrogenase (PDH), (hypoxia-inducible factor 1?) HIF-1? levels and the oral squamous cell carcinoma (OSCC) cell phenotype. Additionally, we also investigated a theoretical consequence of Metformin treatment. METHODS: PDH levels in patients with OSCC and oral dysplasia were evaluated. Metformin was administered in vitro to test the effect of Metformin under hypoxic conditions. The results were complemented by Bioinformatics analyses. CONCLUSIONS: In conclusion, our current findings show that Metformin reduces HIF-1? gene expression and increases PDH expression. Metformin inhibits cell proliferation and migration in the OSCC cell line model. Additionally, Metformin enhances the number of apoptotic cells and caspase 3 levels. Interestingly enough, Metformin did not increase the mutant p53 levels under hypoxic conditions. |Apoptosis/drug effects/genetics [MESH] |Carcinoma, Squamous Cell/*genetics/metabolism/pathology [MESH] |Cell Death/drug effects/genetics [MESH] |Cell Hypoxia [MESH] |Cell Line [MESH] |Cell Line, Tumor [MESH] |Cell Movement/drug effects/genetics [MESH] |Cell Proliferation/drug effects/genetics [MESH] |Gene Expression Regulation, Neoplastic/drug effects [MESH] |Humans [MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/*genetics/metabolism [MESH] |Metformin/*pharmacology [MESH] |Mouth Neoplasms/*genetics/metabolism/pathology [MESH] |Pyruvate Dehydrogenase Complex/*genetics/metabolism [MESH]Metformin increases PDH and suppresses HIF-1? under hypoxic conditions(epmc).pdf DeepDyve Pubget Overpricing