Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.18632/oncotarget.12458 http://scihub22266oqcxt.onion/10.18632/oncotarget.12458 C5342141!5342141 !27713131     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27713131 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2016 ; 7 (44 ): 72021-72032 Nephropedia Template TP {{tp|p=27713131 |t=2016. Discovery of cell surface vimentin targeting mAb for direct disruption of GBM tumor initiating cells |pdf=|usr=}}{{27713131 }} gab.com Text Discovery of cell surface vimentin targeting mAb for direct disruption of GBM tumor initiating cells JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27713131 #FOAvip Intracellular vimentin overexpression has been associated with epithelial-mesenchymal transition, metastasis, invasion, and proliferation, but cell surface vimentin (CSV) is less understood. Furthermore, it remains unknown whether CSV can serve as a therapeutic target in CSV-expressing tumor cells. We found that CSV was present on glioblastoma multiforme (GBM) cancer stem cells and that CSV expression was associated with spheroid formation in those cells. A newly developed monoclonal antibody against CSV, 86C, specifically and significantly induced apoptosis and inhibited spheroid formation in GBM cells in vitro. The addition of 86C to GBM cells in vitro also led to rapid internalization of vimentin and decreased GBM cell viability. These findings were associated with an increase in caspase-3 activity, indicating activation of apoptosis. Finally, treatment with 86C inhibited GBM progression in vivo. In conclusion, CSV-expressing GBM cells have properties of tumor initiating cells, and targeting CSV with the monoclonal antibody 86C is a promising approach in the treatment of GBM. Twit Text FOAVip Discovery of cell surface vimentin targeting mAb for direct disruption of GBM tumor initiating cells ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27713131 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27713131 #FOAvip English Wikipedia <ref>{{Cite pmid|27713131 }}</ref> Discovery of cell surface vimentin targeting mAb for direct disruption of GBM tumor initiating cells #MMPMID27713131 Noh H ; Yan J ; Hong S ; Kong LY ; Gabrusiewicz K ; Xia X ; Heimberger AB ; Li S Oncotarget 2016[Nov]; 7 (44 ): 72021-72032 PMID27713131 show ga Intracellular vimentin overexpression has been associated with epithelial-mesenchymal transition, metastasis, invasion, and proliferation, but cell surface vimentin (CSV) is less understood. Furthermore, it remains unknown whether CSV can serve as a therapeutic target in CSV-expressing tumor cells. We found that CSV was present on glioblastoma multiforme (GBM) cancer stem cells and that CSV expression was associated with spheroid formation in those cells. A newly developed monoclonal antibody against CSV, 86C, specifically and significantly induced apoptosis and inhibited spheroid formation in GBM cells in vitro. The addition of 86C to GBM cells in vitro also led to rapid internalization of vimentin and decreased GBM cell viability. These findings were associated with an increase in caspase-3 activity, indicating activation of apoptosis. Finally, treatment with 86C inhibited GBM progression in vivo. In conclusion, CSV-expressing GBM cells have properties of tumor initiating cells, and targeting CSV with the monoclonal antibody 86C is a promising approach in the treatment of GBM. |Animals [MESH] |Antibodies, Monoclonal/*therapeutic use [MESH] |Apoptosis/drug effects [MESH] |Caspase 3/metabolism [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation [MESH] |Glioblastoma/*drug therapy/pathology [MESH] |Humans [MESH] |Mice [MESH] |Neoplastic Stem Cells/*drug effects/pathology [MESH] |Spheroids, Cellular [MESH]Discovery of cell surface vimentin targeting mAb for direct disruption(epmc).pdf DeepDyve Pubget Overpricing