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10.18632/oncotarget.12378 http://scihub22266oqcxt.onion/10.18632/oncotarget.12378 C5342127!5342127 !27708247     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27708247 &cmd=llinks): Failed to open stream: HTTP request failed! 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Scriptaid overcomes hypoxia-induced cisplatin resistance in both wild-type and mutant p53 lung cancer cells |pdf=|usr=}}{{27708247 }} gab.com Text Scriptaid overcomes hypoxia-induced cisplatin resistance in both wild-type and mutant p53 lung cancer cells JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27708247 #FOAvip Non-small cell lung cancer (NSCLC), comprising 85% of lung cancer cases, has been associated with resistance to chemo/radiotherapy. The hypoxic tumor micro-environment, where insufficient vasculature results in poor drug penetrance and sub-optimal chemotherapy in the tumor interiors contributes heavily to this resistance. Additionally, epigenetic changes in tumorigenic cells also change their response to different forms of therapy. In our study, we have investigated the effectiveness of a combination of cisplatin with scriptaid [a pan-Histone Deacetylase inhibitor (HDACi)] in a model that mimics the tumor microenvironment of hypoxia and sub-lethal chemotherapy. Scriptaid synergistically increases the efficacy of cisplatin in normoxia as well as hypoxia, accompanied with reduced metastasis and enhanced DNA damage. Addition of scriptaid also overcomes the cisplatin resistance exhibited in lung cancer cells with stabilized hypoxia inducible factor 1 (HIF1)-? (mutant) and mutant p53. Molecular studies showed that the combination treatment increased apoptotic cell death in both normoxia and hypoxia with a dual role of p38MAPK. Together, our results suggest that the combination of low dose cisplatin and scriptaid is cytotoxic to NSCLC lines, can overcome hypoxia induced resistance and mutant p53- induced instability often associated with this cancer, and has the potential to be an effective therapeutic modality. Twit Text FOAVip Scriptaid overcomes hypoxia-induced cisplatin resistance in both wild-type and mutant p53 lung cancer cells ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27708247 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27708247 #FOAvip English Wikipedia <ref>{{Cite pmid|27708247 }}</ref> Scriptaid overcomes hypoxia-induced cisplatin resistance in both wild-type and mutant p53 lung cancer cells #MMPMID27708247 Pradhan S ; Mahajan D ; Kaur P ; Pandey N ; Sharma C ; Srivastava T Oncotarget 2016[Nov]; 7 (44 ): 71841-71855 PMID27708247 show ga Non-small cell lung cancer (NSCLC), comprising 85% of lung cancer cases, has been associated with resistance to chemo/radiotherapy. The hypoxic tumor micro-environment, where insufficient vasculature results in poor drug penetrance and sub-optimal chemotherapy in the tumor interiors contributes heavily to this resistance. Additionally, epigenetic changes in tumorigenic cells also change their response to different forms of therapy. In our study, we have investigated the effectiveness of a combination of cisplatin with scriptaid [a pan-Histone Deacetylase inhibitor (HDACi)] in a model that mimics the tumor microenvironment of hypoxia and sub-lethal chemotherapy. Scriptaid synergistically increases the efficacy of cisplatin in normoxia as well as hypoxia, accompanied with reduced metastasis and enhanced DNA damage. Addition of scriptaid also overcomes the cisplatin resistance exhibited in lung cancer cells with stabilized hypoxia inducible factor 1 (HIF1)-? (mutant) and mutant p53. Molecular studies showed that the combination treatment increased apoptotic cell death in both normoxia and hypoxia with a dual role of p38MAPK. Together, our results suggest that the combination of low dose cisplatin and scriptaid is cytotoxic to NSCLC lines, can overcome hypoxia induced resistance and mutant p53- induced instability often associated with this cancer, and has the potential to be an effective therapeutic modality. |*Cell Count [MESH] |*Genes, p53 [MESH] |*Mutation [MESH] |Antineoplastic Combined Chemotherapy Protocols/therapeutic use [MESH] |Apoptosis/drug effects [MESH] |Carcinoma, Non-Small-Cell Lung/*drug therapy/genetics [MESH] |Cell Line, Tumor [MESH] |Cisplatin/administration & dosage/*pharmacology [MESH] |Drug Resistance, Neoplasm [MESH] |Histone Deacetylase Inhibitors/*immunology/pharmacology [MESH] |Humans [MESH] |Hydroxylamines/administration & dosage/*pharmacology [MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/physiology [MESH] |Lung Neoplasms/*drug therapy/genetics [MESH] |Quinolines/administration & dosage/*pharmacology [MESH]Scriptaid overcomes hypoxia-induced cisplatin resistance in both wild-(epmc).pdf DeepDyve Pubget Overpricing