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2016 ; 7
(44
): 71773-71781
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Plasma and tumor levels of Linc-pint are diagnostic and prognostic biomarkers for
pancreatic cancer
#MMPMID27708234
Li L
; Zhang GQ
; Chen H
; Zhao ZJ
; Chen HZ
; Liu H
; Wang G
; Jia YH
; Pan SH
; Kong R
; Wang YW
; Sun B
Oncotarget
2016[Nov]; 7
(44
): 71773-71781
PMID27708234
show ga
Long intergenic non-protein coding RNA, p53 induced transcript (Linc-pint) is a
long noncoding RNA (lncRNA) that regulates tumor cell viability and
proliferation. We used qRT-PCR and RNA FISH analysis to evaluate Linc-pint levels
in the plasma and tumor tissues of pancreatic cancer (PCa) patients. Our data
demonstrate that Linc-pint expression is lower in plasma samples from PCa
patients than from healthy individuals, and indicate that plasma Linc-pint levels
are more sensitive than CA19-9 for detecting PCa. Our data also show that
Linc-pint levels are lower in PCa tumors than in adjacent tissues, carcinoma of
the ampulla of Vater (CAV) and cholangiocarcinoma (CCA), and suggest that
Linc-pint could be used for distinguishing the cause of malignant obstructive
jaundice. Low plasma Linc-pint levels correlate with tumor recurrence, while low
tumor Linc-pint levels correlate with poor prognosis for PCa patients after
pancreatectomy. These results thus indicate that low plasma Linc-pint expression
could serve as a minimally invasive biomarker for early PCa detection, and that
low Linc-pint levels in PCa tumors could be used for predicting patient
prognosis.