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10.18632/oncotarget.12365

http://scihub22266oqcxt.onion/10.18632/oncotarget.12365
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suck abstract from ncbi


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pmid27708234
      Oncotarget 2016 ; 7 (44 ): 71773-71781
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  • Plasma and tumor levels of Linc-pint are diagnostic and prognostic biomarkers for pancreatic cancer #MMPMID27708234
  • Li L ; Zhang GQ ; Chen H ; Zhao ZJ ; Chen HZ ; Liu H ; Wang G ; Jia YH ; Pan SH ; Kong R ; Wang YW ; Sun B
  • Oncotarget 2016[Nov]; 7 (44 ): 71773-71781 PMID27708234 show ga
  • Long intergenic non-protein coding RNA, p53 induced transcript (Linc-pint) is a long noncoding RNA (lncRNA) that regulates tumor cell viability and proliferation. We used qRT-PCR and RNA FISH analysis to evaluate Linc-pint levels in the plasma and tumor tissues of pancreatic cancer (PCa) patients. Our data demonstrate that Linc-pint expression is lower in plasma samples from PCa patients than from healthy individuals, and indicate that plasma Linc-pint levels are more sensitive than CA19-9 for detecting PCa. Our data also show that Linc-pint levels are lower in PCa tumors than in adjacent tissues, carcinoma of the ampulla of Vater (CAV) and cholangiocarcinoma (CCA), and suggest that Linc-pint could be used for distinguishing the cause of malignant obstructive jaundice. Low plasma Linc-pint levels correlate with tumor recurrence, while low tumor Linc-pint levels correlate with poor prognosis for PCa patients after pancreatectomy. These results thus indicate that low plasma Linc-pint expression could serve as a minimally invasive biomarker for early PCa detection, and that low Linc-pint levels in PCa tumors could be used for predicting patient prognosis.
  • |Adult [MESH]
  • |Aged [MESH]
  • |Biomarkers, Tumor/*analysis [MESH]
  • |CA-19-9 Antigen/blood [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Pancreatic Neoplasms/*diagnosis/genetics/pathology [MESH]
  • |Prognosis [MESH]


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