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10.18632/oncotarget.12098 http://scihub22266oqcxt.onion/10.18632/oncotarget.12098 C5342083!5342083!27655681     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2016 ; 7 (44): 71353-61 Nephropedia Template TP {{tp|p=27655681|t=2016. Blood RNA expression profiles undergo major changes during the seventh decade |pdf=|usr=}}{{27655681}} gab.com Text Blood RNA expression profiles undergo major changes during the seventh decade JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27655681 #FOAvip Genome-wide alterations in RNA expression profiles are age-associated. Yet the rate and temporal pattern of those alterations are poorly understood. We investigated temporal changes in RNA expression profiles in blood from population-based studies using a quadratic regression model. Comparative analysis between two independent studies was carried out after sample-weighting that downsized differences in sample distribution over age between the datasets. We show that age-associated expression profiles are clustered into two major inclinations and transcriptional alternations occur predominantly from the seventh decade onwards. The age-associated genes in blood are enriched in functional groups of the translational machinery and the immune system. The results are highly consistent between the two population-based studies indicating that our analysis overcomes potential confounders in population-based studies. We suggest that the critical age when major transcriptional alterations occur could help understanding aging and disease risk during adulthood. Twit Text FOAVip Blood RNA expression profiles undergo major changes during the seventh decade ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27655681 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27655681 #FOAvip English Wikipedia <ref>{{Cite pmid|27655681}}</ref> Blood RNA expression profiles undergo major changes during the seventh decade #MMPMID27655681 Gheorghe M; Schurmann C; Peters MJ; Uitterlinden AG; Hofman A; Biffar R; Homuth G; Völker U; van Meurs JB; Raz V Oncotarget 2016[Nov]; 7 (44): 71353-61 PMID27655681show ga Genome-wide alterations in RNA expression profiles are age-associated. Yet the rate and temporal pattern of those alterations are poorly understood. We investigated temporal changes in RNA expression profiles in blood from population-based studies using a quadratic regression model. Comparative analysis between two independent studies was carried out after sample-weighting that downsized differences in sample distribution over age between the datasets. We show that age-associated expression profiles are clustered into two major inclinations and transcriptional alternations occur predominantly from the seventh decade onwards. The age-associated genes in blood are enriched in functional groups of the translational machinery and the immune system. The results are highly consistent between the two population-based studies indicating that our analysis overcomes potential confounders in population-based studies. We suggest that the critical age when major transcriptional alterations occur could help understanding aging and disease risk during adulthood. äBlood RNA expression profiles undergo major changes during the seventh(epmc).pdf DeepDyve Pubget Overpricing