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10.18632/oncotarget.11217 http://scihub22266oqcxt.onion/10.18632/oncotarget.11217 C5342082!5342082!27533085     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2016 ; 7 (44): 71341-52 Nephropedia Template TP {{tp|p=27533085|t=2016. Halofuginone inhibits radiotherapy-induced epithelial-mesenchymal transition in lung cancer |pdf=|usr=}}{{27533085}} gab.com Text Halofuginone inhibits radiotherapy-induced epithelial-mesenchymal transition in lung cancer JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27533085 #FOAvip Radiotherapy is used to treat many different human tumors. Paradoxically, radiation can activate TGF-?1 signaling and induce the epithelial-mesenchymal transition (EMT), which is associated with enhanced tumor progression. This study investigated the inhibitory effects of halofuginone, a plant-derived alkaloid that has been shown to inhibit TGF-?1 signaling, on radiation-induced EMT and explored the underlying mechanisms using a Lewis lung carcinoma (LLC) xenograft model. The cells and animals were divided into five treatment groups: Normal Control (NC), Halofuginone alone (HF), Radiotherapy alone (RT), Radiotherapy combined with Halofuginone (RT+HF), and Radiotherapy combined with the TGF-?1 inhibitor SB431542 (RT+SB). Radiation induced EMT in lung cancer cells and xenografts, as evidenced by increased expression of the mesenchymal markers N-cadherin and Vimentin, and reduced expression of the epithelial markers E-cadherin and Cytokeratin. Further, radiotherapy treatment increased the migration and invasion of LLC cells. Halofuginone reversed the EMT induced by radiotherapy in vitro and in vivo, and inhibited the migration and invasion of LLC cells. In addition, TGF-?1/Smad signaling was activated by radiotherapy and the mRNA expression of Twist and Snail was elevated; this effect was reversed by halofuginone or the TGF-?1 inhibitor SB431542. Our results demonstrate that halofuginone inhibits radiation-induced EMT, and suggest that suppression of TGF-?1 signaling may be responsible for this effect. Twit Text FOAVip Halofuginone inhibits radiotherapy-induced epithelial-mesenchymal transition in lung cancer ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27533085 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27533085 #FOAvip English Wikipedia <ref>{{Cite pmid|27533085}}</ref> Halofuginone inhibits radiotherapy-induced epithelial-mesenchymal transition in lung cancer #MMPMID27533085 Chen Y; Liu W; Wang P; Hou H; Liu N; Gong L; Wang Y; Ji K; Zhao L; Wang P Oncotarget 2016[Nov]; 7 (44): 71341-52 PMID27533085show ga Radiotherapy is used to treat many different human tumors. Paradoxically, radiation can activate TGF-?1 signaling and induce the epithelial-mesenchymal transition (EMT), which is associated with enhanced tumor progression. This study investigated the inhibitory effects of halofuginone, a plant-derived alkaloid that has been shown to inhibit TGF-?1 signaling, on radiation-induced EMT and explored the underlying mechanisms using a Lewis lung carcinoma (LLC) xenograft model. The cells and animals were divided into five treatment groups: Normal Control (NC), Halofuginone alone (HF), Radiotherapy alone (RT), Radiotherapy combined with Halofuginone (RT+HF), and Radiotherapy combined with the TGF-?1 inhibitor SB431542 (RT+SB). Radiation induced EMT in lung cancer cells and xenografts, as evidenced by increased expression of the mesenchymal markers N-cadherin and Vimentin, and reduced expression of the epithelial markers E-cadherin and Cytokeratin. Further, radiotherapy treatment increased the migration and invasion of LLC cells. Halofuginone reversed the EMT induced by radiotherapy in vitro and in vivo, and inhibited the migration and invasion of LLC cells. In addition, TGF-?1/Smad signaling was activated by radiotherapy and the mRNA expression of Twist and Snail was elevated; this effect was reversed by halofuginone or the TGF-?1 inhibitor SB431542. Our results demonstrate that halofuginone inhibits radiation-induced EMT, and suggest that suppression of TGF-?1 signaling may be responsible for this effect. äHalofuginone inhibits radiotherapy-induced epithelial-mesenchymal tran(epmc).pdf DeepDyve Pubget Overpricing