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10.18632/oncotarget.8460 http://scihub22266oqcxt.onion/10.18632/oncotarget.8460 C5342070!5342070 !27036032     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27036032 &cmd=llinks): Failed to open stream: HTTP request failed! 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Low disabled-2 expression promotes tumor progression and determines poor survival and high recurrence of esophageal squamous cell carcinoma |pdf=|usr=}}{{27036032 }} gab.com Text Low disabled-2 expression promotes tumor progression and determines poor survival and high recurrence of esophageal squamous cell carcinoma JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27036032 #FOAvip Patients with esophageal squamous cell carcinomas (ESCCs) have poor survival and high recurrence rate, but lack a prognostic biomarker. Disabled-2 (DAB2) is a crucial tumor suppressor, but its roles in ESCCs are uncertain. We investigated whether low DAB2 expression in ESCCs could lead into tumor progression and poor prognosis. Our results found patients with low-DAB2 expression ESCCs had significantly larger tumor size, deeper tumor invasion depth, lymph node metastasis, worse survival, and higher recurrence rate (P<0.05). The Cox-regression model revealed low-DAB2 expression was an independent factor of poor survival (P<0.05), and also of tumor recurrence with the predictive performance superior to clinical TNM stage (P<0.05). Low-DAB2 cancer cells, validated by DAB2 knockdown or over-expression, had higher phosphorylated ERK and migration abilities, which could be suppressed by ERK inhibitor treatment. TGF-?-induced epithelial-to-mesenchymal transition (EMT) only existed in the high-DAB2 cells, and related to worse prognosis of high-DAB2 ESCCs (P<0.05). In conclusion, DAB2 can suppress the ERK signaling, but correlate to have TGF-?-induced EMT in ESCCs. DAB2 expression could be a biomarker to identify patients with worse survival and high recurrence. Our data suggest DAB2 expression can stratify patients in need of aggressive surveillance and with possible benefit from anti-ERK or anti-TGF-? therapies. Twit Text FOAVip Low disabled-2 expression promotes tumor progression and determines poor survival and high recurrence of esophageal squamous cell carcinoma ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27036032 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27036032 #FOAvip English Wikipedia <ref>{{Cite pmid|27036032 }}</ref> Low disabled-2 expression promotes tumor progression and determines poor survival and high recurrence of esophageal squamous cell carcinoma #MMPMID27036032 Wang WL ; Chang WL ; Yang HB ; Wang YC ; Chang IW ; Lee CT ; Chang CY ; Lin JT ; Sheu BS Oncotarget 2016[Nov]; 7 (44 ): 71169-71181 PMID27036032 show ga Patients with esophageal squamous cell carcinomas (ESCCs) have poor survival and high recurrence rate, but lack a prognostic biomarker. Disabled-2 (DAB2) is a crucial tumor suppressor, but its roles in ESCCs are uncertain. We investigated whether low DAB2 expression in ESCCs could lead into tumor progression and poor prognosis. Our results found patients with low-DAB2 expression ESCCs had significantly larger tumor size, deeper tumor invasion depth, lymph node metastasis, worse survival, and higher recurrence rate (P<0.05). The Cox-regression model revealed low-DAB2 expression was an independent factor of poor survival (P<0.05), and also of tumor recurrence with the predictive performance superior to clinical TNM stage (P<0.05). Low-DAB2 cancer cells, validated by DAB2 knockdown or over-expression, had higher phosphorylated ERK and migration abilities, which could be suppressed by ERK inhibitor treatment. TGF-?-induced epithelial-to-mesenchymal transition (EMT) only existed in the high-DAB2 cells, and related to worse prognosis of high-DAB2 ESCCs (P<0.05). In conclusion, DAB2 can suppress the ERK signaling, but correlate to have TGF-?-induced EMT in ESCCs. DAB2 expression could be a biomarker to identify patients with worse survival and high recurrence. Our data suggest DAB2 expression can stratify patients in need of aggressive surveillance and with possible benefit from anti-ERK or anti-TGF-? therapies. |Adaptor Proteins, Signal Transducing/analysis/genetics/*physiology [MESH] |Apoptosis Regulatory Proteins [MESH] |Carcinoma, Squamous Cell/*mortality [MESH] |Cell Line, Tumor [MESH] |DNA Methylation [MESH] |Disease Progression [MESH] |Epithelial-Mesenchymal Transition [MESH] |Esophageal Neoplasms/*mortality [MESH] |Esophageal Squamous Cell Carcinoma [MESH] |Extracellular Signal-Regulated MAP Kinases/antagonists & inhibitors/physiology [MESH] |Humans [MESH] |MAP Kinase Signaling System [MESH] |Neoplasm Recurrence, Local/etiology [MESH] |Proportional Hazards Models [MESH] |Transforming Growth Factor beta/antagonists & inhibitors/physiology [MESH]Low disabled-2 expression promotes tumor progression and determines po(epmc).pdf DeepDyve Pubget Overpricing