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10.18632/oncotarget.12187 http://scihub22266oqcxt.onion/10.18632/oncotarget.12187 C5342032!5342032 !27677589     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27677589 &cmd=llinks): Failed to open stream: HTTP request failed! 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FGF4 induces epithelial-mesenchymal transition by inducing store-operated calcium entry in lung adenocarcinoma |pdf=|usr=}}{{27677589 }} gab.com Text FGF4 induces epithelial-mesenchymal transition by inducing store-operated calcium entry in lung adenocarcinoma JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27677589 #FOAvip Several fibroblast growth factor (FGF) isoforms act to stimulate epithelial-mesenchymal transition (EMT) during cancer progression. FGF4 and FGF7 are two ligands of FGF receptor 2 (FGFR2). Using two lung adenocarcinoma (ADC) cell lines, A549 and H1299, we showed that FGF4, but not FGF7, altered cell morphology, promoted EMT-associated protein expression, and enhanced cell proliferation, migration/invasion and colony initiation. In addition, FGF4 increased store-operated calcium entry (SOCE) and expression of the calcium signal-associated protein Orai1. The SOCE inhibitor 2,5-di-tert-butylhydroquinone (BHQ) or Orai1 knockdown reversed all of the EMT-promoting effects of FGF4. BHQ also inhibited FGF4-induced EMT in a mouse xenograft model. Finally, 60 human lung ADC samples and 21 sets of matched specimens (primary and metastatic foci in lymph nodes from one patient) were used to confirm the clinicopathologic significance of FGF4 and its correlation with E-cadherin, Vimentin and Orai1 expression. Our study thus shows that FGF4 induces EMT by elevating SOCE in lung ADC. Twit Text FOAVip FGF4 induces epithelial-mesenchymal transition by inducing store-operated calcium entry in lung adenocarcinoma ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27677589 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27677589 #FOAvip English Wikipedia <ref>{{Cite pmid|27677589 }}</ref> FGF4 induces epithelial-mesenchymal transition by inducing store-operated calcium entry in lung adenocarcinoma #MMPMID27677589 Qi L ; Song W ; Li L ; Cao L ; Yu Y ; Song C ; Wang Y ; Zhang F ; Li Y ; Zhang B ; Cao W Oncotarget 2016[Nov]; 7 (45 ): 74015-74030 PMID27677589 show ga Several fibroblast growth factor (FGF) isoforms act to stimulate epithelial-mesenchymal transition (EMT) during cancer progression. FGF4 and FGF7 are two ligands of FGF receptor 2 (FGFR2). Using two lung adenocarcinoma (ADC) cell lines, A549 and H1299, we showed that FGF4, but not FGF7, altered cell morphology, promoted EMT-associated protein expression, and enhanced cell proliferation, migration/invasion and colony initiation. In addition, FGF4 increased store-operated calcium entry (SOCE) and expression of the calcium signal-associated protein Orai1. The SOCE inhibitor 2,5-di-tert-butylhydroquinone (BHQ) or Orai1 knockdown reversed all of the EMT-promoting effects of FGF4. BHQ also inhibited FGF4-induced EMT in a mouse xenograft model. Finally, 60 human lung ADC samples and 21 sets of matched specimens (primary and metastatic foci in lymph nodes from one patient) were used to confirm the clinicopathologic significance of FGF4 and its correlation with E-cadherin, Vimentin and Orai1 expression. Our study thus shows that FGF4 induces EMT by elevating SOCE in lung ADC. |*Epithelial-Mesenchymal Transition/drug effects [MESH] |Adenocarcinoma of Lung [MESH] |Adenocarcinoma/genetics/*metabolism/*pathology [MESH] |Adult [MESH] |Aged [MESH] |Animals [MESH] |Cadherins/metabolism [MESH] |Calcium/*metabolism [MESH] |Cell Line, Tumor [MESH] |Cell Movement/drug effects [MESH] |Cell Proliferation/drug effects [MESH] |Disease Models, Animal [MESH] |Female [MESH] |Fibroblast Growth Factor 4/*metabolism/pharmacology [MESH] |Fibroblast Growth Factor 7/metabolism/pharmacology [MESH] |Gene Knockdown Techniques [MESH] |Humans [MESH] |Lung Neoplasms/genetics/*metabolism/*pathology [MESH] |Male [MESH] |Mice [MESH] |Middle Aged [MESH] |Neoplasm Grading [MESH] |Neoplasm Metastasis [MESH] |Neoplasm Staging [MESH] |ORAI1 Protein/genetics/metabolism [MESH] |Phenotype [MESH] |Receptor, Fibroblast Growth Factor, Type 2/metabolism [MESH] |Vimentin/metabolism [MESH]FGF4 induces epithelial-mesenchymal transition by inducing store-opera(epmc).pdf DeepDyve Pubget Overpricing