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10.18632/oncotarget.11970 http://scihub22266oqcxt.onion/10.18632/oncotarget.11970 C5341993!5341993 !27636991     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27636991 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2016 ; 7 (45 ): 73486-73496 Nephropedia Template TP {{tp|p=27636991 |t=2016. Oxidized macrophage migration inhibitory factor is a potential new tissue marker and drug target in cancer |pdf=|usr=}}{{27636991 }} gab.com Text Oxidized macrophage migration inhibitory factor is a potential new tissue marker and drug target in cancer JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27636991 #FOAvip Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine, which was shown to be upregulated in cancers and to exhibit tumor promoting properties. Unlike other cytokines, MIF is ubiquitously present in the circulation and tissue of healthy subjects. We recently described a previously unrecognized, disease-related isoform of MIF, designated oxMIF, which is present in the circulation of patients with different inflammatory diseases. In this article, we report that oxMIF is also linked to different solid tumors as it is specifically expressed in tumor tissue from patients with colorectal, pancreatic, ovarian and lung cancer. Furthermore, oxMIF can be specifically targeted by a subset of phage display-derived fully human, monoclonal anti-MIF antibodies (mAbs) that were shown to neutralize pro-tumorigenic activities of MIF in vivo. We further demonstrate that anti-oxMIF mAbs sensitize human cancer cell lines (LNCaP, PC3, A2780 and A2780ADR) to the action of cytotoxic drugs (mitoxantrone, cisplatin and doxorubicin) in vitro and in an A2780 xenograft mouse model of ovarian cancer. We conclude that oxMIF is the disease related isoform of MIF in solid tumors and a potential new diagnostic marker and drug target in cancer. Twit Text FOAVip Oxidized macrophage migration inhibitory factor is a potential new tissue marker and drug target in cancer ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27636991 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27636991 #FOAvip English Wikipedia <ref>{{Cite pmid|27636991 }}</ref> Oxidized macrophage migration inhibitory factor is a potential new tissue marker and drug target in cancer #MMPMID27636991 Schinagl A ; Thiele M ; Douillard P ; Völkel D ; Kenner L ; Kazemi Z ; Freissmuth M ; Scheiflinger F ; Kerschbaumer RJ Oncotarget 2016[Nov]; 7 (45 ): 73486-73496 PMID27636991 show ga Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine, which was shown to be upregulated in cancers and to exhibit tumor promoting properties. Unlike other cytokines, MIF is ubiquitously present in the circulation and tissue of healthy subjects. We recently described a previously unrecognized, disease-related isoform of MIF, designated oxMIF, which is present in the circulation of patients with different inflammatory diseases. In this article, we report that oxMIF is also linked to different solid tumors as it is specifically expressed in tumor tissue from patients with colorectal, pancreatic, ovarian and lung cancer. Furthermore, oxMIF can be specifically targeted by a subset of phage display-derived fully human, monoclonal anti-MIF antibodies (mAbs) that were shown to neutralize pro-tumorigenic activities of MIF in vivo. We further demonstrate that anti-oxMIF mAbs sensitize human cancer cell lines (LNCaP, PC3, A2780 and A2780ADR) to the action of cytotoxic drugs (mitoxantrone, cisplatin and doxorubicin) in vitro and in an A2780 xenograft mouse model of ovarian cancer. We conclude that oxMIF is the disease related isoform of MIF in solid tumors and a potential new diagnostic marker and drug target in cancer. |*Biomarkers, Tumor [MESH] |Antibodies, Monoclonal/pharmacology [MESH] |Antineoplastic Agents/pharmacology [MESH] |Case-Control Studies [MESH] |Cell Line, Tumor [MESH] |Drug Synergism [MESH] |Humans [MESH] |Macrophage Migration-Inhibitory Factors/antagonists & inhibitors/blood/*metabolism [MESH] |Molecular Targeted Therapy [MESH] |Neoplasms/blood/drug therapy/*metabolism/pathology [MESH]Oxidized macrophage migration inhibitory factor is a potential new tis(epmc).pdf DeepDyve Pubget Overpricing