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10.18632/oncotarget.11969 http://scihub22266oqcxt.onion/10.18632/oncotarget.11969 C5341992!5341992 !27636990     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27636990 &cmd=llinks): Failed to open stream: HTTP request failed! 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Recombinant human bone morphogenetic protein-2 inhibits gastric cancer cell proliferation by inactivating Wnt signaling pathway via c-Myc with aurora kinases |pdf=|usr=}}{{27636990 }} gab.com Text Recombinant human bone morphogenetic protein-2 inhibits gastric cancer cell proliferation by inactivating Wnt signaling pathway via c-Myc with aurora kinases JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27636990 #FOAvip The detailed molecular mechanisms and safety issues of recombinant human bone morphogenetic protein-2 (rhBMP-2) usage in bone graft substitution remain poorly understood. To investigate the molecular mechanisms underlying the function of rhBMP-2 in gastric cancer cells, we used microarrays to determine the gene expression patterns related to the effects of rhBMP-2. Based on a gene ontology analysis, several genes were upregulated during the regulation of the cell cycle and BMP signaling pathway. MYC was found to be significantly decreased along with its downstream target genes, the aurora kinases (AURKs), by rhBMP-2 in the network analysis. We further confirmed this finding with western blot data that rhBMP-2 inhibited c-Myc, AURKs, and ?-catenin in SNU484 and SNU638 cells. An AURK inhibitor significantly decreased c-Myc expression in gastric cancer cells. Combination treatment with rhBMP-2 and AURK inhibitor resulted in significantly decreased c-Myc expression compared with gastric cancer cells treated with an rhBMP-2 or AURK inhibitor, respectively. Similar effects for decreased c-Myc expression were observed when we silenced ?-catenin in gastric cancer cells. These results indicate that rhBMP-2 attenuated the growth of gastric cancer cells via the inactivation of ?-catenin via c-Myc and AURKs. Therefore, our findings suggest that rhBMP-2 could be safely used with patients who undergo gastric or gastroesophageal cancer surgery. Twit Text FOAVip Recombinant human bone morphogenetic protein-2 inhibits gastric cancer cell proliferation by inactivating Wnt signaling pathway via c-Myc with aurora kinases ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27636990 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27636990 #FOAvip English Wikipedia <ref>{{Cite pmid|27636990 }}</ref> Recombinant human bone morphogenetic protein-2 inhibits gastric cancer cell proliferation by inactivating Wnt signaling pathway via c-Myc with aurora kinases #MMPMID27636990 Lee KB ; Jin H ; Ye S ; Park BH ; Kim SM Oncotarget 2016[Nov]; 7 (45 ): 73473-73485 PMID27636990 show ga The detailed molecular mechanisms and safety issues of recombinant human bone morphogenetic protein-2 (rhBMP-2) usage in bone graft substitution remain poorly understood. To investigate the molecular mechanisms underlying the function of rhBMP-2 in gastric cancer cells, we used microarrays to determine the gene expression patterns related to the effects of rhBMP-2. Based on a gene ontology analysis, several genes were upregulated during the regulation of the cell cycle and BMP signaling pathway. MYC was found to be significantly decreased along with its downstream target genes, the aurora kinases (AURKs), by rhBMP-2 in the network analysis. We further confirmed this finding with western blot data that rhBMP-2 inhibited c-Myc, AURKs, and ?-catenin in SNU484 and SNU638 cells. An AURK inhibitor significantly decreased c-Myc expression in gastric cancer cells. Combination treatment with rhBMP-2 and AURK inhibitor resulted in significantly decreased c-Myc expression compared with gastric cancer cells treated with an rhBMP-2 or AURK inhibitor, respectively. Similar effects for decreased c-Myc expression were observed when we silenced ?-catenin in gastric cancer cells. These results indicate that rhBMP-2 attenuated the growth of gastric cancer cells via the inactivation of ?-catenin via c-Myc and AURKs. Therefore, our findings suggest that rhBMP-2 could be safely used with patients who undergo gastric or gastroesophageal cancer surgery. |Aurora Kinases/*metabolism [MESH] |Bone Morphogenetic Protein 2/genetics/metabolism/*pharmacology [MESH] |Cell Cycle/drug effects [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation/drug effects [MESH] |Gene Expression Profiling [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Humans [MESH] |Neoplastic Stem Cells/drug effects/metabolism [MESH] |Proto-Oncogene Proteins c-myc/*metabolism [MESH] |Recombinant Proteins/pharmacology [MESH] |Smad Proteins/metabolism [MESH] |Stomach Neoplasms/genetics/metabolism [MESH] |Transforming Growth Factor beta/*pharmacology [MESH] |Tumor Stem Cell Assay [MESH]Recombinant human bone morphogenetic protein-2 inhibits gastric cancer(epmc).pdf DeepDyve Pubget Overpricing