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2016 ; 7
(45
): 73280-73291
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
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English Wikipedia
Thermo-sensitive composite hydrogels based on poloxamer 407 and alginate and
their therapeutic effect in embolization in rabbit VX2 liver tumors
#MMPMID27602579
Huang L
; Shen M
; Li R
; Zhang X
; Sun Y
; Gao P
; Fu H
; Liu H
; He Y
; Du Y
; Cao J
; Duan Y
Oncotarget
2016[Nov]; 7
(45
): 73280-73291
PMID27602579
show ga
Interventional embolization therapy is an effective, most widely used method for
inoperable liver tumors. Blood-vessel-embolic agents were essential in
transarterial embolization (TAE). In this work, thermo-sensitive composite
hydrogels based on poloxamer 407, sodium alginate, hydroxymethyl cellulose and
iodixanol (PSHI), together with Ca2+ (PSHI-Ca2+) were prepared as liquid embolic
agents for TAE therapy to liver cancer. With increasing temperature, PSHI
exhibited two phase states: a flowing sol and a shrunken gel. Rheology tests
showed good fluidity and excellent viscoelastic behavior with a gelation
temperature (GT) of 26.5°C. The studies of erosion indicated that PSHI had
calcium ion-related erosion characteristics and showed a slow erosion rate in an
aqueous environment. When incubated with L929 cells, the thermo-sensitive
composite hydrogels had low cytotoxicity in vitro. The results of analyzing the
digital subtraction angiography and computed tomography images obtained from in
vitro and in vivo assays indicated a good embolic effect in the renal arteries of
normal rabbits. Angiography and histological studies on VX2 tumor-bearing rabbits
indicated that PSHI-Ca2+ successfully occluded the tumors, including the
peripheral vessels. In conclusion, PSHI-Ca2+ was a promising embolic agent for
transarterial embolization therapy.