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10.18632/oncotarget.11789

http://scihub22266oqcxt.onion/10.18632/oncotarget.11789
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C5341979!5341979 !27602579
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suck abstract from ncbi


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pmid27602579
      Oncotarget 2016 ; 7 (45 ): 73280-73291
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  • Thermo-sensitive composite hydrogels based on poloxamer 407 and alginate and their therapeutic effect in embolization in rabbit VX2 liver tumors #MMPMID27602579
  • Huang L ; Shen M ; Li R ; Zhang X ; Sun Y ; Gao P ; Fu H ; Liu H ; He Y ; Du Y ; Cao J ; Duan Y
  • Oncotarget 2016[Nov]; 7 (45 ): 73280-73291 PMID27602579 show ga
  • Interventional embolization therapy is an effective, most widely used method for inoperable liver tumors. Blood-vessel-embolic agents were essential in transarterial embolization (TAE). In this work, thermo-sensitive composite hydrogels based on poloxamer 407, sodium alginate, hydroxymethyl cellulose and iodixanol (PSHI), together with Ca2+ (PSHI-Ca2+) were prepared as liquid embolic agents for TAE therapy to liver cancer. With increasing temperature, PSHI exhibited two phase states: a flowing sol and a shrunken gel. Rheology tests showed good fluidity and excellent viscoelastic behavior with a gelation temperature (GT) of 26.5°C. The studies of erosion indicated that PSHI had calcium ion-related erosion characteristics and showed a slow erosion rate in an aqueous environment. When incubated with L929 cells, the thermo-sensitive composite hydrogels had low cytotoxicity in vitro. The results of analyzing the digital subtraction angiography and computed tomography images obtained from in vitro and in vivo assays indicated a good embolic effect in the renal arteries of normal rabbits. Angiography and histological studies on VX2 tumor-bearing rabbits indicated that PSHI-Ca2+ successfully occluded the tumors, including the peripheral vessels. In conclusion, PSHI-Ca2+ was a promising embolic agent for transarterial embolization therapy.
  • |*Alginates/chemistry [MESH]
  • |*Embolization, Therapeutic/methods [MESH]
  • |*Hydrogels/chemistry [MESH]
  • |*Poloxamer/chemistry [MESH]
  • |Animals [MESH]
  • |Calcium/chemistry [MESH]
  • |Disease Models, Animal [MESH]
  • |Glucuronic Acid/chemistry [MESH]
  • |Hexuronic Acids/chemistry [MESH]
  • |Immunohistochemistry [MESH]
  • |Ions/chemistry [MESH]
  • |Liver Neoplasms/diagnostic imaging/*pathology/therapy [MESH]
  • |Rabbits [MESH]
  • |Renal Artery/diagnostic imaging/pathology [MESH]
  • |Rheology [MESH]
  • |Temperature [MESH]


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