Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27556502
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27556502
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Oncotarget
2016 ; 7
(41
): 66660-66678
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Overexpression of CHKA contributes to tumor progression and metastasis and
predicts poor prognosis in colorectal carcinoma
#MMPMID27556502
Hu L
; Wang RY
; Cai J
; Feng D
; Yang GZ
; Xu QG
; Zhai YX
; Zhang Y
; Zhou WP
; Cai QP
Oncotarget
2016[Oct]; 7
(41
): 66660-66678
PMID27556502
show ga
Aberrant expression of choline kinase alpha (CHKA) has been reported in a variety
of human malignancies including colorectal carcinoma (CRC). However, the role of
CHKA in the progression and prognosis of CRC remains unknown. In this study, we
found that CHKA was frequently upregulated in CRC clinical samples and
CRC-derived cell lines and was significantly correlated with lymph node
metastasis (p = 0.028), TNM stage (p = 0.009), disease recurrence (p = 0.004) and
death (p < 0.001). Survival analyses indicated that patients with higher CHKA
expression had a significantly shorter disease-free survival (DFS) and
disease-specific survival (DSS) than those with lower CHKA expression.
Multivariate analyses confirmed that increased CHKA expression was an independent
unfavorable prognostic factor for CRC patients. In addition, combination of CHKA
with TNM stage was a more powerful predictor of poor prognosis than either
parameter alone. Functional study demonstrated that knockdown of CHKA expression
profoundly suppressed the growth and metastasis of CRC cells both in vitro and in
vivo. Mechanistic investigation revealed that EGFR/PI3K/AKT pathway was essential
for mediating CHKA function. In conclusion, our results provide the first
evidence that CHKA contributes to tumor progression and metastasis and may serve
as a novel prognostic biomarker and potential therapeutic target in CRC.
free
free
free
