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10.1038/ncb3335 http://scihub22266oqcxt.onion/10.1038/ncb3335 C5341796!5341796!27043084     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Cell+Biol 2016 ; 18 (5): 527-39 Nephropedia Template TP {{tp|p=27043084|t=2016. HSF1 critically attunes proteotoxic-stress sensing by mTORC1 to combat stress and promote growth |pdf=|usr=}}{{27043084}} gab.com Text HSF1 critically attunes proteotoxic-stress sensing by mTORC1 to combat stress and promote growth JO: Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27043084 #FOAvip To cope with proteotoxic stress, cells attenuate protein synthesis. However, the precise mechanisms underlying this fundamental adaptation remain poorly defined. Here we report that mTORC1 acts as an immediate cellular sensor of proteotoxic stress. Surprisingly, the multifaceted stress-responsive kinase JNK constitutively associates with mTORC1 under normal growth conditions. Upon activation by proteotoxic stress, JNK phosphorylates both RAPTOR at Ser863 and mTOR at Ser567, causing partial disintegration of mTORC1 and subsequent translation inhibition. Importantly, HSF1, the central player in the proteotoxic stress response (PSR), preserves mTORC1 integrity and function by inactivating JNK, independently of its canonical transcriptional action. Thereby, HSF1 translationally augments the PSR. Beyond promoting stress resistance, this intricate HSF1-JNK-mTORC1 interplay, strikingly, regulates cell, organ and body sizes. Thus, these results illuminate a unifying mechanism that controls stress adaptation and growth. Twit Text FOAVip HSF1 critically attunes proteotoxic-stress sensing by mTORC1 to combat stress and promote growth ????Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27043084 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27043084 #FOAvip English Wikipedia <ref>{{Cite pmid|27043084}}</ref> HSF1 critically attunes proteotoxic-stress sensing by mTORC1 to combat stress and promote growth #MMPMID27043084 Su KH; Cao J; Tang Z; Dai S; He Y; Sampson SB; Benjamin IJ; Dai C Nat Cell Biol 2016[May]; 18 (5): 527-39 PMID27043084show ga To cope with proteotoxic stress, cells attenuate protein synthesis. However, the precise mechanisms underlying this fundamental adaptation remain poorly defined. Here we report that mTORC1 acts as an immediate cellular sensor of proteotoxic stress. Surprisingly, the multifaceted stress-responsive kinase JNK constitutively associates with mTORC1 under normal growth conditions. Upon activation by proteotoxic stress, JNK phosphorylates both RAPTOR at Ser863 and mTOR at Ser567, causing partial disintegration of mTORC1 and subsequent translation inhibition. Importantly, HSF1, the central player in the proteotoxic stress response (PSR), preserves mTORC1 integrity and function by inactivating JNK, independently of its canonical transcriptional action. Thereby, HSF1 translationally augments the PSR. Beyond promoting stress resistance, this intricate HSF1-JNK-mTORC1 interplay, strikingly, regulates cell, organ and body sizes. Thus, these results illuminate a unifying mechanism that controls stress adaptation and growth. äHSF1 critically attunes proteotoxic-stress sensing by mTORC1 to combat(epmc).pdf DeepDyve Pubget Overpricing