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10.1615/ForumImmunDisTher.2015014188 http://scihub22266oqcxt.onion/10.1615/ForumImmunDisTher.2015014188 C5341794!5341794!28286692     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       For+Immunopathol+Dis+Therap 2015 ; 6 (1-2): 7-17 Nephropedia Template TP {{tp|p=28286692|t=2015. Reinvigorating Exhausted T Cells by Blockade of the PD-1 Pathway |pdf=|usr=}}{{28286692}} gab.com Text Reinvigorating Exhausted T Cells by Blockade of the PD-1 Pathway JO: For Immunopathol Dis Therap http://www.kidney.de/pget.php?&tw=1&pmid=28286692 #FOAvip T-cell exhaustion due to persistent antigen stimulation is a key feature of chronic viral infections and cancer. Programmed cell death-1 (PD-1) is a major regulator of T-cell exhaustion, and blocking the PD-1 pathway restores T-cell function and improves pathogen control and tumor eradication. Immunotherapy targeting the PD-1 inhibitory receptor pathway has demonstrated significant antitumor activity. Recently, antibodies blocking PD-1 have been approved for use in cancer patients. In this review, we summarize the role of the PD-1 pathway in chronic infection and cancer and the therapeutic potential of PD-1-directed immunotherapy in patients with chronic infection or cancer. Twit Text FOAVip Reinvigorating Exhausted T Cells by Blockade of the PD-1 Pathway ????For Immunopathol Dis Therap http://www.kidney.de/pget.php?&tw=1&pmid=28286692 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28286692 #FOAvip English Wikipedia <ref>{{Cite pmid|28286692}}</ref> Reinvigorating Exhausted T Cells by Blockade of the PD-1 Pathway #MMPMID28286692 Lee J; Ahn E; Kissick HT; Ahmed R For Immunopathol Dis Therap 2015[]; 6 (1-2): 7-17 PMID28286692show ga T-cell exhaustion due to persistent antigen stimulation is a key feature of chronic viral infections and cancer. Programmed cell death-1 (PD-1) is a major regulator of T-cell exhaustion, and blocking the PD-1 pathway restores T-cell function and improves pathogen control and tumor eradication. Immunotherapy targeting the PD-1 inhibitory receptor pathway has demonstrated significant antitumor activity. Recently, antibodies blocking PD-1 have been approved for use in cancer patients. In this review, we summarize the role of the PD-1 pathway in chronic infection and cancer and the therapeutic potential of PD-1-directed immunotherapy in patients with chronic infection or cancer. äReinvigorating Exhausted T Cells by Blockade of the PD-1 Pathway (epmc).pdf DeepDyve Pubget Overpricing