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10.1038/nrneph.2016.9 http://scihub22266oqcxt.onion/10.1038/nrneph.2016.9 C5341793!5341793!26923209     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Rev+Nephrol 2016 ; 12 (6): 339-47 Nephropedia Template TP {{tp|p=26923209|t=2016. Memory T cells in organ transplantation: progress and challenges |pdf=|usr=}}{{26923209}} gab.com Text Memory T cells in organ transplantation: progress and challenges JO: Nat Rev Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=26923209 #FOAvip Antigen-experienced T cells, also known as memory T cells, are functionally and phenotypically distinct from naive T cells. Their enhanced expression of adhesion molecules and reduced requirement for co-stimulation enables them to mount potent and rapid recall responses to subsequent antigen encounters. Memory T cells generated in response to prior antigen exposures can cross-react with other nonidentical, but similar, antigens. This heterologous cross-reactivity not only enhances protective immune responses, but also engenders de novo alloimmunity. This latter characteristic is increasingly recognized as a potential barrier to allograft acceptance that is worthy of immunotherapeutic intervention, and several approaches have been investigated. Calcineurin inhibition effectively controls memory T-cell responses to allografts, but this benefit comes at the expense of increased infectious morbidity. Lymphocyte depletion eliminates allospecific T cells but spares memory T cells to some extent, such that patients do not completely lose protective immunity. Co-stimulation blockade is associated with reduced adverse-effect profiles and improved graft function relative to calcineurin inhibition, but lacks efficacy in controlling memory T-cell responses. Targeting the adhesion molecules that are upregulated on memory T cells might offer additional means to control co-stimulation-blockade-resistant memory T-cell responses. Twit Text FOAVip Memory T cells in organ transplantation: progress and challenges ????Nat Rev Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=26923209 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26923209 #FOAvip English Wikipedia <ref>{{Cite pmid|26923209}}</ref> Memory T cells in organ transplantation: progress and challenges #MMPMID26923209 Espinosa JR; Samy KP; Kirk AD Nat Rev Nephrol 2016[Jun]; 12 (6): 339-47 PMID26923209show ga Antigen-experienced T cells, also known as memory T cells, are functionally and phenotypically distinct from naive T cells. Their enhanced expression of adhesion molecules and reduced requirement for co-stimulation enables them to mount potent and rapid recall responses to subsequent antigen encounters. Memory T cells generated in response to prior antigen exposures can cross-react with other nonidentical, but similar, antigens. This heterologous cross-reactivity not only enhances protective immune responses, but also engenders de novo alloimmunity. This latter characteristic is increasingly recognized as a potential barrier to allograft acceptance that is worthy of immunotherapeutic intervention, and several approaches have been investigated. Calcineurin inhibition effectively controls memory T-cell responses to allografts, but this benefit comes at the expense of increased infectious morbidity. Lymphocyte depletion eliminates allospecific T cells but spares memory T cells to some extent, such that patients do not completely lose protective immunity. Co-stimulation blockade is associated with reduced adverse-effect profiles and improved graft function relative to calcineurin inhibition, but lacks efficacy in controlling memory T-cell responses. Targeting the adhesion molecules that are upregulated on memory T cells might offer additional means to control co-stimulation-blockade-resistant memory T-cell responses. äMemory T cells in organ transplantation: progress and challenges (epmc).pdf DeepDyve Pubget Overpricing