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10.1091/mbc.E16-03-0149 http://scihub22266oqcxt.onion/10.1091/mbc.E16-03-0149 C5341720!5341720!28137949     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Biol+Cell 2017 ; 28 (3): 364-9 Nephropedia Template TP {{tp|p=28137949|t=2017. Genetic and epigenetic control of the spatial organization of the genome |pdf=|usr=}}{{28137949}} gab.com Text Genetic and epigenetic control of the spatial organization of the genome JO: Mol Biol Cell http://www.kidney.de/pget.php?&tw=1&pmid=28137949 #FOAvip Eukaryotic genomes are spatially organized within the nucleus by chromosome folding, interchromosomal contacts, and interaction with nuclear structures. This spatial organization is observed in diverse organisms and both reflects and contributes to gene expression and differentiation. This leads to the notion that the arrangement of the genome within the nucleus has been shaped and conserved through evolutionary processes and likely plays an adaptive function. Both DNA-binding proteins and changes in chromatin structure influence the positioning of genes and larger domains within the nucleus. This suggests that the spatial organization of the genome can be genetically encoded by binding sites for DNA-binding proteins and can also involve changes in chromatin structure, potentially through nongenetic mechanisms. Here I briefly discuss the results that support these ideas and their implications for how genomes encode spatial organization. Twit Text FOAVip Genetic and epigenetic control of the spatial organization of the genome ????Mol Biol Cell http://www.kidney.de/pget.php?&tw=1&pmid=28137949 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28137949 #FOAvip English Wikipedia <ref>{{Cite pmid|28137949}}</ref> Genetic and epigenetic control of the spatial organization of the genome #MMPMID28137949 Brickner J Mol Biol Cell 2017[Feb]; 28 (3): 364-9 PMID28137949show ga Eukaryotic genomes are spatially organized within the nucleus by chromosome folding, interchromosomal contacts, and interaction with nuclear structures. This spatial organization is observed in diverse organisms and both reflects and contributes to gene expression and differentiation. This leads to the notion that the arrangement of the genome within the nucleus has been shaped and conserved through evolutionary processes and likely plays an adaptive function. Both DNA-binding proteins and changes in chromatin structure influence the positioning of genes and larger domains within the nucleus. This suggests that the spatial organization of the genome can be genetically encoded by binding sites for DNA-binding proteins and can also involve changes in chromatin structure, potentially through nongenetic mechanisms. Here I briefly discuss the results that support these ideas and their implications for how genomes encode spatial organization. äGenetic and epigenetic control of the spatial organization of the geno(epmc).pdf DeepDyve Pubget Overpricing