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10.1186/s13045-017-0432-0

http://scihub22266oqcxt.onion/10.1186/s13045-017-0432-0
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C5341419!5341419!28270163
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suck abstract from ncbi

pmid28270163      J+Hematol+Oncol 2017 ; 10 (ä): ä
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  • T-ALL and thymocytes: a message of noncoding RNAs #MMPMID28270163
  • Wallaert A; Durinck K; Taghon T; Van Vlierberghe P; Speleman F
  • J Hematol Oncol 2017[]; 10 (ä): ä PMID28270163show ga
  • In the last decade, the role for noncoding RNAs in disease was clearly established, starting with microRNAs and later expanded towards long noncoding RNAs. This was also the case for T cell acute lymphoblastic leukemia, which is a malignant blood disorder arising from oncogenic events during normal T cell development in the thymus. By studying the transcriptomic profile of protein-coding genes, several oncogenic events leading to T cell acute lymphoblastic leukemia (T-ALL) could be identified. In recent years, it became apparent that several of these oncogenes function via microRNAs and long noncoding RNAs. In this review, we give a detailed overview of the studies that describe the noncoding RNAome in T-ALL oncogenesis and normal T cell development.
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