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10.18632/oncotarget.13128 http://scihub22266oqcxt.onion/10.18632/oncotarget.13128 C5341258!5341258 !27825143     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27825143 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2016 ; 7 (50 ): 83462-83475 Nephropedia Template TP {{tp|p=27825143 |t=2016. Tristetraprolin disables prostate cancer maintenance by impairing proliferation and metabolic function |pdf=|usr=}}{{27825143 }} gab.com Text Tristetraprolin disables prostate cancer maintenance by impairing proliferation and metabolic function JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27825143 #FOAvip Tristetraprolin (TTP) is an RNA-binding protein that post-transcriptionally suppresses gene expression by delivering mRNA cargo to processing bodies (P-bodies) where the mRNA is degraded. TTP functions as a tumor suppressor in a mouse model of B cell lymphoma, and in some human malignancies low TTP expression correlates with reduced survival. Here we report important prognostic and functional roles for TTP in human prostate cancer. First, gene expression analysis of prostate tumors revealed low TTP expression correlates with patients having high-risk Gleason scores and increased biochemical recurrence. Second, in prostate cancer cells with low levels of endogenous TTP, inducible TTP expression inhibits their growth and proliferation, as well as their clonogenic growth. Third, TTP functions as a tumor suppressor in prostate cancer, as forced TTP expression markedly impairs the tumorigenic potential of prostate cancer cells in a mouse xenograft model. Finally, pathway analysis of gene expression data suggested metabolism is altered by TTP expression in prostate tumor cells, and metabolic analyses revealed that such processes are impaired by TTP, including mitochondrial respiration. Collectively, these findings suggest that TTP is an important prognostic indicator for prostate cancer, and augmenting TTP function would effectively disable the metabolism and proliferation of aggressive prostate tumors. Twit Text FOAVip Tristetraprolin disables prostate cancer maintenance by impairing proliferation and metabolic function ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27825143 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27825143 #FOAvip English Wikipedia <ref>{{Cite pmid|27825143 }}</ref> Tristetraprolin disables prostate cancer maintenance by impairing proliferation and metabolic function #MMPMID27825143 Berglund AE ; Scott KE ; Li W ; Yang C ; Fernandez MR ; Schaub FX ; Cleveland JL ; Rounbehler RJ Oncotarget 2016[Dec]; 7 (50 ): 83462-83475 PMID27825143 show ga Tristetraprolin (TTP) is an RNA-binding protein that post-transcriptionally suppresses gene expression by delivering mRNA cargo to processing bodies (P-bodies) where the mRNA is degraded. TTP functions as a tumor suppressor in a mouse model of B cell lymphoma, and in some human malignancies low TTP expression correlates with reduced survival. Here we report important prognostic and functional roles for TTP in human prostate cancer. First, gene expression analysis of prostate tumors revealed low TTP expression correlates with patients having high-risk Gleason scores and increased biochemical recurrence. Second, in prostate cancer cells with low levels of endogenous TTP, inducible TTP expression inhibits their growth and proliferation, as well as their clonogenic growth. Third, TTP functions as a tumor suppressor in prostate cancer, as forced TTP expression markedly impairs the tumorigenic potential of prostate cancer cells in a mouse xenograft model. Finally, pathway analysis of gene expression data suggested metabolism is altered by TTP expression in prostate tumor cells, and metabolic analyses revealed that such processes are impaired by TTP, including mitochondrial respiration. Collectively, these findings suggest that TTP is an important prognostic indicator for prostate cancer, and augmenting TTP function would effectively disable the metabolism and proliferation of aggressive prostate tumors. |*Cell Proliferation/drug effects [MESH] |*Energy Metabolism/drug effects [MESH] |Animals [MESH] |Antibiotics, Antineoplastic/pharmacology [MESH] |Cell Line, Tumor [MESH] |Disease-Free Survival [MESH] |Dose-Response Relationship, Drug [MESH] |Doxorubicin/pharmacology [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Gene Regulatory Networks [MESH] |Humans [MESH] |Kallikreins/blood [MESH] |Male [MESH] |Mice, Nude [MESH] |Neoplasm Grading [MESH] |Prostate-Specific Antigen/blood [MESH] |Prostatic Neoplasms/drug therapy/genetics/*metabolism/pathology [MESH] |Signal Transduction [MESH] |Time Factors [MESH] |Tristetraprolin/genetics/*metabolism [MESH] |Tumor Suppressor Proteins/genetics/*metabolism [MESH]Tristetraprolin disables prostate cancer maintenance by impairing prol(epmc).pdf DeepDyve Pubget Overpricing