Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1111/bph.13397 http://scihub22266oqcxt.onion/10.1111/bph.13397 C5341236!5341236!26660048     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Br+J+Pharmacol 2016 ; 173 (6): 980-91 Nephropedia Template TP {{tp|p=26660048|t=2016. Genipin alleviates sepsis?induced liver injury by restoring autophagy |pdf=|usr=}}{{26660048}} gab.com Text Genipin alleviates sepsis induced liver injury by restoring autophagy JO: Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=26660048 #FOAvip Background and Purpose: Autophagy is an essential cytoprotective system that is rapidly activated in response to various stimuli including inflammation and microbial infection. Genipin, an aglycon of geniposide found in gardenia fruit, is well known to have anti?inflammatory, antibacterial and antioxidative properties. This study examined the protective mechanisms of genipin against sepsis, with particular focus on the autophagic signalling pathway. Experimental Approach: Mice were subjected to sepsis by caecal ligation and puncture (CLP). Genipin (1, 2.5 and 5 mg·kg?1) or vehicle (saline) was injected i.v. immediately (0 h) after CLP, and chloroquine (60 mg·kg?1), an autophagy inhibitor, was injected i.p. 1 h before CLP. Blood and liver tissues were isolated 6 h after CLP. Key Results: Genipin improved survival rate and decreased serum levels of aminotransferases and pro?inflammatory cytokines after CLP; effects abolished by chloroquine. The liver expression of autophagy?related protein (Atg)12?Atg5 conjugate increased after CLP, and this increase was enhanced by genipin. CLP decreased Atg3 protein liver expression, and genipin attenuated this decrease. CLP impaired autophagic flux, as indicated by increased liver expression of microtubule?associated protein?1 light chain 3?II and sequestosome?1/p62 protein; this impaired autophagic flux was restored by genipin, and chloroquine abolished this effect. Genipin also attenuated the decreased expression of lysosome?associated membrane protein?2 and Rab7 protein and increased expression of calpain 1 protein induced by CLP in the liver. Conclusions and Implications: Our findings suggest that genipin protects against septic injury by restoring impaired autophagic flux. Therefore, genipin might be a potential therapeutic agent for the treatment of sepsis. Twit Text FOAVip Genipin alleviates sepsis induced liver injury by restoring autophagy ????Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=26660048 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26660048 #FOAvip English Wikipedia <ref>{{Cite pmid|26660048}}</ref> Genipin alleviates sepsis?induced liver injury by restoring autophagy #MMPMID26660048 Cho H; Kim S; Choi J; Lee S Br J Pharmacol 2016[Mar]; 173 (6): 980-91 PMID26660048show ga Background and Purpose: Autophagy is an essential cytoprotective system that is rapidly activated in response to various stimuli including inflammation and microbial infection. Genipin, an aglycon of geniposide found in gardenia fruit, is well known to have anti?inflammatory, antibacterial and antioxidative properties. This study examined the protective mechanisms of genipin against sepsis, with particular focus on the autophagic signalling pathway. Experimental Approach: Mice were subjected to sepsis by caecal ligation and puncture (CLP). Genipin (1, 2.5 and 5 mg·kg?1) or vehicle (saline) was injected i.v. immediately (0 h) after CLP, and chloroquine (60 mg·kg?1), an autophagy inhibitor, was injected i.p. 1 h before CLP. Blood and liver tissues were isolated 6 h after CLP. Key Results: Genipin improved survival rate and decreased serum levels of aminotransferases and pro?inflammatory cytokines after CLP; effects abolished by chloroquine. The liver expression of autophagy?related protein (Atg)12?Atg5 conjugate increased after CLP, and this increase was enhanced by genipin. CLP decreased Atg3 protein liver expression, and genipin attenuated this decrease. CLP impaired autophagic flux, as indicated by increased liver expression of microtubule?associated protein?1 light chain 3?II and sequestosome?1/p62 protein; this impaired autophagic flux was restored by genipin, and chloroquine abolished this effect. Genipin also attenuated the decreased expression of lysosome?associated membrane protein?2 and Rab7 protein and increased expression of calpain 1 protein induced by CLP in the liver. Conclusions and Implications: Our findings suggest that genipin protects against septic injury by restoring impaired autophagic flux. Therefore, genipin might be a potential therapeutic agent for the treatment of sepsis. äGenipin alleviates sepsis?induced liver injury by restoring autophagy (epmc).pdf DeepDyve Pubget Overpricing