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10.1111/bph.13373 http://scihub22266oqcxt.onion/10.1111/bph.13373 C5341226!5341226!26505736     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Br+J+Pharmacol 2016 ; 173 (2): 319-31 Nephropedia Template TP {{tp|p=26505736|t=2016. Prostaglandin E2 inhibits neutrophil extracellular trap formation through production of cyclic AMP |pdf=|usr=}}{{26505736}} gab.com Text Prostaglandin E2 inhibits neutrophil extracellular trap formation through production of cyclic AMP JO: Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=26505736 #FOAvip Background and Purpose: Upon stimulation, neutrophils release their nuclear contents called neutrophil extracellular traps (NETs), which contain unfolded chromatin and lysosomal enzymes. NETs have been demonstrated to play a critical role in host defence, although the role of PGE2, a bioactive substance generated in inflammatory tissues, in the formation of NETs remains unclear. Experimental Approach: The effects of PGE2, agonists and antagonists of its receptors, and modulators of the cAMP?PKA pathway on the formation of NETs were examined in vitro in isolated neutrophils and in vivo in a newly established mouse model. Key Results: PGE2 inhibited PMA?induced NET formation in vitro through EP2 and EP4 G?s?coupled receptors. Incubation with a cell?permeable cAMP analogue, dibutyryl cAMP, or various inhibitors of a cAMP?degrading enzyme, PDE, also suppressed NET formation. In the assay established here, where an agarose gel was s.c. implanted in mice and NET formation was detected on the surface of the gel, the extent of the NET formed was inhibited in agarose gels containing rolipram, a PDE4 inhibitor, and butaprost, an EP2 receptor agonist. Conclusions and Implications: PGE2 inhibits NET formation through the production of cAMP. These findings will contribute to the development of novel treatments for NETosis?related diseases. Twit Text FOAVip Prostaglandin E2 inhibits neutrophil extracellular trap formation through production of cyclic AMP ????Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=26505736 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26505736 #FOAvip English Wikipedia <ref>{{Cite pmid|26505736}}</ref> Prostaglandin E2 inhibits neutrophil extracellular trap formation through production of cyclic AMP #MMPMID26505736 Shishikura K; Horiuchi T; Sakata N; Trinh D; Shirakawa R; Kimura T; Asada Y; Horiuchi H Br J Pharmacol 2016[Jan]; 173 (2): 319-31 PMID26505736show ga Background and Purpose: Upon stimulation, neutrophils release their nuclear contents called neutrophil extracellular traps (NETs), which contain unfolded chromatin and lysosomal enzymes. NETs have been demonstrated to play a critical role in host defence, although the role of PGE2, a bioactive substance generated in inflammatory tissues, in the formation of NETs remains unclear. Experimental Approach: The effects of PGE2, agonists and antagonists of its receptors, and modulators of the cAMP?PKA pathway on the formation of NETs were examined in vitro in isolated neutrophils and in vivo in a newly established mouse model. Key Results: PGE2 inhibited PMA?induced NET formation in vitro through EP2 and EP4 G?s?coupled receptors. Incubation with a cell?permeable cAMP analogue, dibutyryl cAMP, or various inhibitors of a cAMP?degrading enzyme, PDE, also suppressed NET formation. In the assay established here, where an agarose gel was s.c. implanted in mice and NET formation was detected on the surface of the gel, the extent of the NET formed was inhibited in agarose gels containing rolipram, a PDE4 inhibitor, and butaprost, an EP2 receptor agonist. Conclusions and Implications: PGE2 inhibits NET formation through the production of cAMP. These findings will contribute to the development of novel treatments for NETosis?related diseases. äProstaglandin E2 inhibits neutrophil extracellular trap formation thro(epmc).pdf DeepDyve Pubget Overpricing