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2017 ; 12
(1
): 14
Nephropedia Template TP
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English Wikipedia
Towards a cardiac allocation score: a retrospective calculation for 73 patients
from a German transplant center
#MMPMID28270168
Claes S
; Berchtold-Herz M
; Zhou Q
; Trummer G
; Bock M
; Zirlik A
; Beyersdorf F
; Bode C
; Grundmann S
J Cardiothorac Surg
2017[Mar]; 12
(1
): 14
PMID28270168
show ga
BACKGROUND: Due to a growing discrepancy between the transplant waiting list and
decreasing numbers of available donor hearts, cardiac transplantation rates in
Germany have been declining in the past years. Currently, patients on the waiting
list are prioritized by medical urgency and waiting time and therefore a majority
of all cardiac transplants is performed in very ill patients. Recently, a
different allocation algorithm was proposed that included predicted
post-transplant survival as a parameter for organ allocation. So far, little data
exists on how such a "Cardiac Allocation Score" (CAS) relates to our current
transplant patient population and on how such a change in organ allocation could
change clinical practice. METHODS: We calculated a theoretical retrospective
Cardiac Allocation Score for 73 patients recruited and transplanted at our
medium-volume center in Germany based on a hypothetical scoring algorithm
recently published by Eurotransplant. RESULTS: Overall, 37 patients (50.7%) were
transplanted on high urgency status (HU), 27 (37%) were being supported by a VAD
at time of transplant. 57 (78.1%) were male. We found a relatively normal
distribution of the hypothetical CAS with a median of 32.91 and a mean of 31.95
+/-10.02. Overall, CAS-Scores were lower than previously described for a
Eurotransplant patient cohort of high urgency patients, but there was a
significant overlap in score values between patients on HU and T status.
CAS-values of VAD-supported patients were lower than in patients without
mechanical support. The IMPACT-score as part of the CAS was used for prediction
of post-transplant survival and seems suitable to predict outcome in our patient
population. CONCLUSION: In a retrospective analysis, the recently proposed
Cardiac Allocation Score seems to show a normal distribution of priority values
in our patient cohort. The IMPACT-score predicted outcome after transplantation
and could serve as part of the CAS-algorithm to predict post-transplant survival
in this single center real-world scenario. Implementation of the CAS could
significantly change organ allocation practice, including a potential
prioritization of current T-status patients over HU-status patients.
|*Algorithms
[MESH]
|*Heart Transplantation
[MESH]
|*Waiting Lists
[MESH]
|Adolescent
[MESH]
|Adult
[MESH]
|Aged
[MESH]
|Female
[MESH]
|Germany/epidemiology
[MESH]
|Graft Survival
[MESH]
|Heart Failure/mortality/*surgery
[MESH]
|Humans
[MESH]
|Male
[MESH]
|Middle Aged
[MESH]
|Prognosis
[MESH]
|Retrospective Studies
[MESH]
|Survival Rate/trends
[MESH]
|Tissue Donors/*supply & distribution
[MESH]
|Tissue and Organ Procurement/*organization & administration
[MESH]