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10.1038/srep43960 http://scihub22266oqcxt.onion/10.1038/srep43960 C5341020!5341020!28272516     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28272516|t=2017. The ligand-bound thyroid hormone receptor in macrophages ameliorates kidney injury via inhibition of nuclear factor-?B activities |pdf=|usr=}}{{28272516}} gab.com Text The ligand-bound thyroid hormone receptor in macrophages ameliorates kidney injury via inhibition of nuclear factor- B activities JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28272516 #FOAvip In chronic kidney disease (CKD) patients, inflammation plays a pivotal role in the progression of renal fibrosis. Hypothyroidism is associated with an increased occurrence of atherosclerosis and inflammation, suggesting protective roles of thyroid hormones and their receptors against inflammatory processes. The contribution of thyroid hormone receptors to macrophage differentiation has not been well documented. Here, we focused on the endogenous thyroid hormone receptor ? (TR?) in macrophages and examined the role of ligand-bound TR? in macrophage polarization-mediated anti-inflammatory effects. TR?-deficient irradiated chimeric mice showed exacerbated tubulointerstitial injury in a unilateral ureteral obstruction model. Compared with wild-type macrophages, macrophages isolated from the obstructed kidneys of mice lacking TR? displayed increased expression of proinflammatory cytokines that was accompanied by enhanced nuclear translocation of p65. Comparison of TR?-deficient bone marrow-derived macrophages with wild-type macrophages confirmed the propensity of the former cells to produce excessive IL-1? levels. Co-culture of these macrophages with renal epithelial cells induced more severe damage to the epithelial cells via the IL-1 receptor. Our findings indicate that ligand-bound TR? on macrophages plays a protective role in kidney inflammation through the inhibition of NF-?B pathways, possibly by affecting the pro- and anti-inflammatory balance that controls the development of CKD. Twit Text FOAVip The ligand-bound thyroid hormone receptor in macrophages ameliorates kidney injury via inhibition of nuclear factor- B activities ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28272516 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28272516 #FOAvip English Wikipedia <ref>{{Cite pmid|28272516}}</ref> The ligand-bound thyroid hormone receptor in macrophages ameliorates kidney injury via inhibition of nuclear factor-?B activities #MMPMID28272516 Furuya F; Ishii T; Tamura S; Takahashi K; Kobayashi H; Ichijo M; Takizawa S; Kaneshige M; Suzuki-Inoue K; Kitamura K Sci Rep 2017[]; 7 (ä): ä PMID28272516show ga In chronic kidney disease (CKD) patients, inflammation plays a pivotal role in the progression of renal fibrosis. Hypothyroidism is associated with an increased occurrence of atherosclerosis and inflammation, suggesting protective roles of thyroid hormones and their receptors against inflammatory processes. The contribution of thyroid hormone receptors to macrophage differentiation has not been well documented. Here, we focused on the endogenous thyroid hormone receptor ? (TR?) in macrophages and examined the role of ligand-bound TR? in macrophage polarization-mediated anti-inflammatory effects. TR?-deficient irradiated chimeric mice showed exacerbated tubulointerstitial injury in a unilateral ureteral obstruction model. Compared with wild-type macrophages, macrophages isolated from the obstructed kidneys of mice lacking TR? displayed increased expression of proinflammatory cytokines that was accompanied by enhanced nuclear translocation of p65. Comparison of TR?-deficient bone marrow-derived macrophages with wild-type macrophages confirmed the propensity of the former cells to produce excessive IL-1? levels. Co-culture of these macrophages with renal epithelial cells induced more severe damage to the epithelial cells via the IL-1 receptor. Our findings indicate that ligand-bound TR? on macrophages plays a protective role in kidney inflammation through the inhibition of NF-?B pathways, possibly by affecting the pro- and anti-inflammatory balance that controls the development of CKD. äThe ligand-bound thyroid hormone receptor in macrophages ameliorates k(epmc).pdf DeepDyve Pubget Overpricing