Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28248890
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Effect of contraindicated drugs for heart failure on hospitalization among
seniors with heart failure: A nested case-control study
#MMPMID28248890
Girouard C
; Grégoire JP
; Poirier P
; Moisan J
Medicine (Baltimore)
2017[Mar]; 96
(9
): e6239
PMID28248890
show ga
Little is known about the effect of nonsteroidal anti-inflammatory drugs
(NSAIDs), thiazolidinediones (TZDs), nifedipine and nondihydropyridine calcium
channel blockers (CCBs) usage on the risk of all-cause hospitalization among
seniors with heart failure (HF). We assessed the risk of all-cause
hospitalization associated with exposure to each of these drug classes, in a
population of seniors with HF.Using the Quebec provincial databases, we conducted
a nested case-control study in a population of individuals aged ?65 with a first
HF diagnosis between 2000 and 2009. Patients were considered users of a
potentially inappropriate drug class if their date of hospital admission occurred
in the interval between the date of the last drug claim and the end date of its
days' supply. The risks of hospitalization were estimated using multivariate
conditional logistic regression.Of the 128,853 individuals included in the study
population, 101,273 (78.6%) were hospitalized. When compared to nonusers, users
of NSAIDs (adjusted odds ratio: 1.16; 95% confidence interval: 1.13-1.20), TZD
(1.09; 1.04-1.14), and CCBs (1.03; 1.01-1.05) had an increased risk of all-cause
hospitalization, but not the users of nifedipine (1.00; 0.97-1.03).Seniors with
HF exposed to a potentially inappropriate drug class are at increased risk of
worse health outcomes. Treatment alternatives should be considered, as they are
available.
|*Anti-Inflammatory Agents, Non-Steroidal
[MESH]
|*Calcium Channel Blockers
[MESH]
|*Heart Failure
[MESH]
|*Nifedipine
[MESH]
|*Thiazolidinediones
[MESH]
|Aged
[MESH]
|Aged, 80 and over
[MESH]
|Case-Control Studies
[MESH]
|Contraindications
[MESH]
|Female
[MESH]
|Hospitalization/*statistics & numerical data
[MESH]
free
free
free
