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10.1007/978-1-4939-3372-3_5

http://scihub22266oqcxt.onion/10.1007/978-1-4939-3372-3_5
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C5340310!5340310!26895047
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suck abstract from ncbi


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pmid26895047      Methods+Mol+Biol 2016 ; 1400 (ä): 79-93
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  • Long Interspersed Element Sequencing (L1-Seq): A Method to Identify Somatic LINE-1 Insertions in the Human Genome #MMPMID26895047
  • Doucet TT; Kazazian HH
  • Methods Mol Biol 2016[]; 1400 (ä): 79-93 PMID26895047show ga
  • L1-seq is a high-throughput sequencing technique which is utilized to identify novel L1 insertions in genomic DNA samples of interest. Using special diagnostic nucleotides unique to the youngest and most active L1 sequence, we can amplify new somatic insertions. This technique has helped to establish the number of L1 insertions present in the general population as well as the variation among individuals with regard to their complement of active L1 elements. More recently, this technique has been employed to assess the level of retrotransposition occurring in various diseases such as cancer. These efforts try to establish a connection between the process of retrotransposition and disease development and/or progression.
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