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10.1016/j.bbamcr.2010.03.008 http://scihub22266oqcxt.onion/10.1016/j.bbamcr.2010.03.008 C5340308!5340308!20307590     free     free     free       Biochim+Biophys+Acta 2010 ; 1803 (7): 786-95 Nephropedia Template TP {{tp|p=20307590|t=2010. Hedgehog signaling and gastrointestinal cancer |pdf=|usr=}}{{20307590}} gab.com Text Hedgehog signaling and gastrointestinal cancer JO: Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=20307590 #FOAvip Hedgehog (Hh) signaling is critical for embryonic development and in differentiation, proliferation, and maintenance of multiple adult tissues. De-regulation of the Hh pathway is associated with birth defects and cancer. In the gastrointestinal tract, Hh ligands Sonic (Shh) and Indian (Ihh), as well as the receptor Patched (Ptch1), and transcription factors of Glioblastoma family (Gli) are all expressed during development. In the adult, Shh expression is restricted to the stomach and colon, while Ihh expression occurs throughout the luminal gastrointestinal tract, its expression being highest in the proximal duodenum. Several studies have demonstrated a requirement for Hh signaling during gastrointestinal tract development. However to date, the specific role of the Hh pathway in the adult stomach and intestine is not completely understood. The current review will place into context the implications of recent published data related to the biochemistry and cell biology of Hh signaling on the luminal gastrointestinal tract during development, normal physiology and subsequently carcinogenesis. Twit Text FOAVip Hedgehog signaling and gastrointestinal cancer ????Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=20307590 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20307590 #FOAvip English Wikipedia <ref>{{Cite pmid|20307590}}</ref> Hedgehog signaling and gastrointestinal cancer #MMPMID20307590 Saqui-Salces M; Merchant JL Biochim Biophys Acta 2010[Jul]; 1803 (7): 786-95 PMID20307590show ga Hedgehog (Hh) signaling is critical for embryonic development and in differentiation, proliferation, and maintenance of multiple adult tissues. De-regulation of the Hh pathway is associated with birth defects and cancer. In the gastrointestinal tract, Hh ligands Sonic (Shh) and Indian (Ihh), as well as the receptor Patched (Ptch1), and transcription factors of Glioblastoma family (Gli) are all expressed during development. In the adult, Shh expression is restricted to the stomach and colon, while Ihh expression occurs throughout the luminal gastrointestinal tract, its expression being highest in the proximal duodenum. Several studies have demonstrated a requirement for Hh signaling during gastrointestinal tract development. However to date, the specific role of the Hh pathway in the adult stomach and intestine is not completely understood. The current review will place into context the implications of recent published data related to the biochemistry and cell biology of Hh signaling on the luminal gastrointestinal tract during development, normal physiology and subsequently carcinogenesis. äHedgehog signaling and gastrointestinal cancer (epmc).pdf DeepDyve Pubget Overpricing