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10.1038/ni1136 http://scihub22266oqcxt.onion/10.1038/ni1136 C5340300!5340300!15531885     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Immunol 2004 ; 5 (12): 1227-34 Nephropedia Template TP {{tp|p=15531885|t=2004. Bone marrow plasmacytoid dendritic cells can differentiate into myeloid dendritic cells upon virus infection |pdf=|usr=}}{{15531885}} gab.com Text Bone marrow plasmacytoid dendritic cells can differentiate into myeloid dendritic cells upon virus infection JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=15531885 #FOAvip Two subsets of dendritic cell (DCs), plasmacytoid (p) and myeloid (m) DCs, have been described in humans and mice. These subsets are known to have divergent roles during an immune response, but their developmental course is unclear. Here we report that virus infection induces bone marrow pDCs to differentiate into mDCs, thereby undergoing profound phenotypic and functional changes including the acquisition of enhanced antigen-presenting capacity and the ability to recognize different microbial structures through Toll-like receptor 4. The conversion of pDCs into mDCs is also induced by the injection of double-stranded RNA and requires type I interferons. Our results establish a precursor-product developmental relationship between these two DC subsets and highlight unexpected plasticity of bone marrow pDCs. Twit Text FOAVip Bone marrow plasmacytoid dendritic cells can differentiate into myeloid dendritic cells upon virus infection ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=15531885 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=15531885 #FOAvip English Wikipedia <ref>{{Cite pmid|15531885}}</ref> Bone marrow plasmacytoid dendritic cells can differentiate into myeloid dendritic cells upon virus infection #MMPMID15531885 Zuniga EI; McGavern DB; Pruneda-Paz JL; Teng C; Oldstone MBA Nat Immunol 2004[Dec]; 5 (12): 1227-34 PMID15531885show ga Two subsets of dendritic cell (DCs), plasmacytoid (p) and myeloid (m) DCs, have been described in humans and mice. These subsets are known to have divergent roles during an immune response, but their developmental course is unclear. Here we report that virus infection induces bone marrow pDCs to differentiate into mDCs, thereby undergoing profound phenotypic and functional changes including the acquisition of enhanced antigen-presenting capacity and the ability to recognize different microbial structures through Toll-like receptor 4. The conversion of pDCs into mDCs is also induced by the injection of double-stranded RNA and requires type I interferons. Our results establish a precursor-product developmental relationship between these two DC subsets and highlight unexpected plasticity of bone marrow pDCs. äBone marrow plasmacytoid dendritic cells can differentiate into myeloi(epmc).pdf DeepDyve Pubget Overpricing