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10.4161/rna.6.2.7727 http://scihub22266oqcxt.onion/10.4161/rna.6.2.7727 C5340298!5340298 !19246992     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=19246992 &cmd=llinks): Failed to open stream: HTTP request failed! 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Roseoflavin is a natural antibacterial compound that binds to FMN riboswitches and regulates gene expression |pdf=|usr=}}{{19246992 }} gab.com Text Roseoflavin is a natural antibacterial compound that binds to FMN riboswitches and regulates gene expression JO: RNA Biol http://www.kidney.de/pget.php?&tw=1&pmid=19246992 #FOAvip Riboswitches in messenger RNAs carry receptor domains called aptamers that can bind to metabolites and control expression of associated genes. The Gram-positive bacterium Bacillus subtilis has two representatives of a class of riboswitches that bind flavin mononucleotide (FMN). These riboswitches control genes responsible for the biosynthesis and transport of riboflavin, a precursor of FMN. We found that roseoflavin, a chemical analog of FMN and riboflavin that has antimicrobial activity, can directly bind to FMN riboswitch aptamers and downregulate the expression of an FMN riboswitch-lacZ reporter gene in B. subtilis. A role for the riboswitch in the antimicrobial mechanism of roseoflavin is supported by our observation that some previously identified roseoflavin-resistant bacteria have mutations within an FMN aptamer. Riboswitch mutations in these resistant bacteria disrupt ligand binding and derepress reporter gene expression in the presence of either riboflavin or roseoflavin. If FMN riboswitches are a major target for roseoflavin antimicrobial action, then future efforts to develop compounds that trigger FMN riboswitch function could lead to the identification of new antimicrobial drugs. Twit Text FOAVip Roseoflavin is a natural antibacterial compound that binds to FMN riboswitches and regulates gene expression ????RNA Biol http://www.kidney.de/pget.php?&tw=1&pmid=19246992 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19246992 #FOAvip English Wikipedia <ref>{{Cite pmid|19246992 }}</ref> Roseoflavin is a natural antibacterial compound that binds to FMN riboswitches and regulates gene expression #MMPMID19246992 Lee ER ; Blount KF ; Breaker RR RNA Biol 2009[Apr]; 6 (2 ): 187-94 PMID19246992 show ga Riboswitches in messenger RNAs carry receptor domains called aptamers that can bind to metabolites and control expression of associated genes. The Gram-positive bacterium Bacillus subtilis has two representatives of a class of riboswitches that bind flavin mononucleotide (FMN). These riboswitches control genes responsible for the biosynthesis and transport of riboflavin, a precursor of FMN. We found that roseoflavin, a chemical analog of FMN and riboflavin that has antimicrobial activity, can directly bind to FMN riboswitch aptamers and downregulate the expression of an FMN riboswitch-lacZ reporter gene in B. subtilis. A role for the riboswitch in the antimicrobial mechanism of roseoflavin is supported by our observation that some previously identified roseoflavin-resistant bacteria have mutations within an FMN aptamer. Riboswitch mutations in these resistant bacteria disrupt ligand binding and derepress reporter gene expression in the presence of either riboflavin or roseoflavin. If FMN riboswitches are a major target for roseoflavin antimicrobial action, then future efforts to develop compounds that trigger FMN riboswitch function could lead to the identification of new antimicrobial drugs. |Anti-Bacterial Agents/*pharmacology [MESH] |Bacillus subtilis/drug effects/genetics/growth & development [MESH] |Base Sequence [MESH] |Flavin Mononucleotide/*metabolism [MESH] |Gene Expression Regulation, Bacterial/*drug effects [MESH] |Genes, Bacterial [MESH] |Molecular Sequence Data [MESH] |Mutation [MESH] |Nucleic Acid Conformation [MESH] |RNA, Bacterial/chemistry/genetics [MESH]Roseoflavin is a natural antibacterial compound that binds to FMN ribo(epmc).pdf DeepDyve Pubget Overpricing