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10.18632/oncotarget.12967 http://scihub22266oqcxt.onion/10.18632/oncotarget.12967 C5340238!5340238!27806330     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2016 ; 7 (48): 79774-86 Nephropedia Template TP {{tp|p=27806330|t=2016. Plasma glutamate carboxypeptidase is a negative regulator in liver cancer metastasis |pdf=|usr=}}{{27806330}} gab.com Text Plasma glutamate carboxypeptidase is a negative regulator in liver cancer metastasis JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27806330 #FOAvip Tumor metastasis is the leading cause of cancer death. In the metastatic process, EMT is a unique phenotypic change that plays an important role in cell invasion and changes in cell morphology. Despite the clinical significance, the mechanism underlying tumor metastasis is still poorly understood. Here we report a novel mechanism by which secreted plasma glutamate carboxypeptidase(PGCP) negatively involves Wnt/?-catenin signaling by DKK4 regulation in liver cancer metastasis. Pathway analysis of the RNA sequencing data showed that PGCP knockdown in liver cancer cell lines enriched the functions of cell migration, motility and mesenchymal cell differentiation. Depletion of PGCP promoted cell migration and invasion via activation of Wnt/?-catenin signaling pathway components such as phospho-LRP6 and ?-catenin. Also, addition of DKK4 antagonized the Wnt/?-catenin signaling cascade in a thyroxine (T4)-dependent manner. In an in vivo study, metastatic nodules were observed in the lungs of the mice after injection of shPGCP stable cell lines. Our findings suggest that PGCP negatively associates with Wnt/?-catenin signaling during metastasis. Targeting this regulation may represent a novel and effective therapeutic option for liver cancer by preventing metastatic activity of primary tumor cells. Twit Text FOAVip Plasma glutamate carboxypeptidase is a negative regulator in liver cancer metastasis ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27806330 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27806330 #FOAvip English Wikipedia <ref>{{Cite pmid|27806330}}</ref> Plasma glutamate carboxypeptidase is a negative regulator in liver cancer metastasis #MMPMID27806330 Lee JH; Cho HS; Lee JJ; Jun SY; Ahn JH; Min JS; Yoon JY; Choi MH; Jeon SJ; Lim JH; Jung CR; Kim DS; Kim HT; Factor VM; Lee YH; Thorgeirsson SS; Kim CH; Kim NS Oncotarget 2016[Nov]; 7 (48): 79774-86 PMID27806330show ga Tumor metastasis is the leading cause of cancer death. In the metastatic process, EMT is a unique phenotypic change that plays an important role in cell invasion and changes in cell morphology. Despite the clinical significance, the mechanism underlying tumor metastasis is still poorly understood. Here we report a novel mechanism by which secreted plasma glutamate carboxypeptidase(PGCP) negatively involves Wnt/?-catenin signaling by DKK4 regulation in liver cancer metastasis. Pathway analysis of the RNA sequencing data showed that PGCP knockdown in liver cancer cell lines enriched the functions of cell migration, motility and mesenchymal cell differentiation. Depletion of PGCP promoted cell migration and invasion via activation of Wnt/?-catenin signaling pathway components such as phospho-LRP6 and ?-catenin. Also, addition of DKK4 antagonized the Wnt/?-catenin signaling cascade in a thyroxine (T4)-dependent manner. In an in vivo study, metastatic nodules were observed in the lungs of the mice after injection of shPGCP stable cell lines. Our findings suggest that PGCP negatively associates with Wnt/?-catenin signaling during metastasis. Targeting this regulation may represent a novel and effective therapeutic option for liver cancer by preventing metastatic activity of primary tumor cells. äPlasma glutamate carboxypeptidase is a negative regulator in liver can(epmc).pdf DeepDyve Pubget Overpricing