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10.18632/oncotarget.12584 http://scihub22266oqcxt.onion/10.18632/oncotarget.12584 C5340177!5340177 !27738315     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27738315 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2016 ; 7 (46 ): 76062-76075 Nephropedia Template TP {{tp|p=27738315 |t=2016. Hedgehog and TGF? signaling converge on Gli2 to control bony invasion and bone destruction in oral squamous cell carcinoma |pdf=|usr=}}{{27738315 }} gab.com Text Hedgehog and TGF signaling converge on Gli2 to control bony invasion and bone destruction in oral squamous cell carcinoma JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27738315 #FOAvip Oral Squamous Cell Carcinoma (OSCC) is the sixth most common cancer worldwide. OSCC invasion into the lymph nodes and mandible correlates with increased rates of recurrence and lower overall survival. Tumors that infiltrate mandibular bone proliferate rapidly and induce bone destruction. While survival rates have increased 12% over the last 20 years, this improvement is attributed to general advances in prevention, earlier detection, and updated treatments. Additionally, despite decades of research, the molecular mechanisms of OSCC invasion into the mandible are not well understood. Parathyroid Hormone-related Protein (PTHrP), has been shown to be essential for mandibular invasion in OSCC animal models, and our previous studies demonstrate that the transcription factor Gli2 increases PTHrP expression in tumor metastasis to bone. In OSCC, we investigated regulators of Gli2, including Hedgehog, TGF?, and Wnt signaling to elucidate how PTHrP expression is controlled. Here we show that canonical Hedgehog and TGF? signaling cooperate to increase PTHrP expression and mandibular invasion in a Gli2-dependent manner. Additionally, in an orthotopic model of mandibular invasion, inhibition of Gli2 using shRNA resulted in a significant decrease of both PTHrP expression and bony invasion. Collectively, our findings demonstrate that multiple signaling pathways converge on Gli2 to mediate PTHrP expression and bony invasion, highlighting Gli2 as a therapeutic target to prevent bony invasion in OSCC. Twit Text FOAVip Hedgehog and TGF signaling converge on Gli2 to control bony invasion and bone destruction in oral squamous cell carcinoma ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27738315 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27738315 #FOAvip English Wikipedia <ref>{{Cite pmid|27738315 }}</ref> Hedgehog and TGF? signaling converge on Gli2 to control bony invasion and bone destruction in oral squamous cell carcinoma #MMPMID27738315 Cannonier SA ; Gonzales CB ; Ely K ; Guelcher SA ; Sterling JA Oncotarget 2016[Nov]; 7 (46 ): 76062-76075 PMID27738315 show ga Oral Squamous Cell Carcinoma (OSCC) is the sixth most common cancer worldwide. OSCC invasion into the lymph nodes and mandible correlates with increased rates of recurrence and lower overall survival. Tumors that infiltrate mandibular bone proliferate rapidly and induce bone destruction. While survival rates have increased 12% over the last 20 years, this improvement is attributed to general advances in prevention, earlier detection, and updated treatments. Additionally, despite decades of research, the molecular mechanisms of OSCC invasion into the mandible are not well understood. Parathyroid Hormone-related Protein (PTHrP), has been shown to be essential for mandibular invasion in OSCC animal models, and our previous studies demonstrate that the transcription factor Gli2 increases PTHrP expression in tumor metastasis to bone. In OSCC, we investigated regulators of Gli2, including Hedgehog, TGF?, and Wnt signaling to elucidate how PTHrP expression is controlled. Here we show that canonical Hedgehog and TGF? signaling cooperate to increase PTHrP expression and mandibular invasion in a Gli2-dependent manner. Additionally, in an orthotopic model of mandibular invasion, inhibition of Gli2 using shRNA resulted in a significant decrease of both PTHrP expression and bony invasion. Collectively, our findings demonstrate that multiple signaling pathways converge on Gli2 to mediate PTHrP expression and bony invasion, highlighting Gli2 as a therapeutic target to prevent bony invasion in OSCC. |Animals [MESH] |Bone and Bones/diagnostic imaging/*pathology [MESH] |Carcinoma, Squamous Cell/diagnostic imaging/genetics/*metabolism/*pathology [MESH] |Cell Line, Tumor [MESH] |Disease Models, Animal [MESH] |Gene Expression [MESH] |Hedgehog Proteins/*metabolism [MESH] |Heterografts [MESH] |Humans [MESH] |Mice [MESH] |Mouth Neoplasms/diagnostic imaging/genetics/*metabolism/*pathology [MESH] |Neoplasm Invasiveness [MESH] |Nuclear Proteins/*metabolism [MESH] |Parathyroid Hormone-Related Protein/genetics/metabolism [MESH] |Signal Transduction [MESH] |Transforming Growth Factor beta/*metabolism [MESH]Hedgehog and TGF? signaling converge on Gli2 to control bony invasion (epmc).pdf DeepDyve Pubget Overpricing