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10.1038/srep43502 http://scihub22266oqcxt.onion/10.1038/srep43502 C5339865!5339865!28266553     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28266553|t=2017. Experimental Evaluation of Kidney Regeneration by Organ Scaffold Recellularization |pdf=|usr=}}{{28266553}} gab.com Text Experimental Evaluation of Kidney Regeneration by Organ Scaffold Recellularization JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28266553 #FOAvip The rising number of patients needing renal replacement therapy, alongside the significant clinical and economic limitations of current therapies, creates an imperative need for new strategies to treat kidney diseases. Kidney bioengineering through the production of acellular scaffolds and recellularization with stem cells is one potential strategy. While protocols for obtaining organ scaffolds have been developed successfully, scaffold recellularization is more challenging. We evaluated the potential of in vivo and in vitro kidney scaffold recellularization procedures. Our results show that acellular scaffolds implanted in rats cannot be repopulated with host cells, and in vitro recellularization is necessary. However, we obtained very limited and inconsistent cell seeding when using different infusion protocols, regardless of injection site. We also obtained experimental and theoretical data indicating that uniform cell delivery into the kidney scaffolds cannot be obtained using these infusion protocols, due to the permeability of the extracellular matrix of the scaffold. Our results highlight the major physical barriers that limit in vitro recellularization of acellular kidney scaffolds and the obstacles that must be investigated to effectively advance this strategy for regenerative medicine. Twit Text FOAVip Experimental Evaluation of Kidney Regeneration by Organ Scaffold Recellularization ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28266553 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28266553 #FOAvip English Wikipedia <ref>{{Cite pmid|28266553}}</ref> Experimental Evaluation of Kidney Regeneration by Organ Scaffold Recellularization #MMPMID28266553 Remuzzi A; Figliuzzi M; Bonandrini B; Silvani S; Azzollini N; Nossa R; Benigni A; Remuzzi G Sci Rep 2017[]; 7 (ä): ä PMID28266553show ga The rising number of patients needing renal replacement therapy, alongside the significant clinical and economic limitations of current therapies, creates an imperative need for new strategies to treat kidney diseases. Kidney bioengineering through the production of acellular scaffolds and recellularization with stem cells is one potential strategy. While protocols for obtaining organ scaffolds have been developed successfully, scaffold recellularization is more challenging. We evaluated the potential of in vivo and in vitro kidney scaffold recellularization procedures. Our results show that acellular scaffolds implanted in rats cannot be repopulated with host cells, and in vitro recellularization is necessary. However, we obtained very limited and inconsistent cell seeding when using different infusion protocols, regardless of injection site. We also obtained experimental and theoretical data indicating that uniform cell delivery into the kidney scaffolds cannot be obtained using these infusion protocols, due to the permeability of the extracellular matrix of the scaffold. Our results highlight the major physical barriers that limit in vitro recellularization of acellular kidney scaffolds and the obstacles that must be investigated to effectively advance this strategy for regenerative medicine. äExperimental Evaluation of Kidney Regeneration by Organ Scaffold Recel(epmc).pdf DeepDyve Pubget Overpricing