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10.1038/srep43761 http://scihub22266oqcxt.onion/10.1038/srep43761 C5339821!5339821!28266621     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28266621|t=2017. Large-scale human skin lipidomics by quantitative, high-throughput shotgun mass spectrometry |pdf=|usr=}}{{28266621}} gab.com Text Large-scale human skin lipidomics by quantitative, high-throughput shotgun mass spectrometry JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28266621 #FOAvip The lipid composition of human skin is essential for its function; however the simultaneous quantification of a wide range of stratum corneum (SC) and sebaceous lipids is not trivial. We developed and validated a quantitative high-throughput shotgun mass spectrometry-based platform for lipid analysis of tape-stripped SC skin samples. It features coverage of 16 lipid classes; total quantification to the level of individual lipid molecules; high reproducibility and high-throughput capabilities. With this method we conducted a large lipidomic survey of 268 human SC samples, where we investigated the relationship between sampling depth and lipid composition, lipidome variability in samples from 14 different sampling sites on the human body and finally, we assessed the impact of age and sex on lipidome variability in 104 healthy subjects. We found sebaceous lipids to constitute an abundant component of the SC lipidome as they diffuse into the topmost SC layers forming a gradient. Lipidomic variability with respect to sampling depth, site and subject is considerable, and mainly accredited to sebaceous lipids, while stratum corneum lipids vary less. This stresses the importance of sampling design and the role of sebaceous lipids in skin studies. Twit Text FOAVip Large-scale human skin lipidomics by quantitative, high-throughput shotgun mass spectrometry ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28266621 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28266621 #FOAvip English Wikipedia <ref>{{Cite pmid|28266621}}</ref> Large-scale human skin lipidomics by quantitative, high-throughput shotgun mass spectrometry #MMPMID28266621 Sadowski T; Klose C; Gerl MJ; Wójcik-Maciejewicz A; Herzog R; Simons K; Reich A; Surma MA Sci Rep 2017[]; 7 (ä): ä PMID28266621show ga The lipid composition of human skin is essential for its function; however the simultaneous quantification of a wide range of stratum corneum (SC) and sebaceous lipids is not trivial. We developed and validated a quantitative high-throughput shotgun mass spectrometry-based platform for lipid analysis of tape-stripped SC skin samples. It features coverage of 16 lipid classes; total quantification to the level of individual lipid molecules; high reproducibility and high-throughput capabilities. With this method we conducted a large lipidomic survey of 268 human SC samples, where we investigated the relationship between sampling depth and lipid composition, lipidome variability in samples from 14 different sampling sites on the human body and finally, we assessed the impact of age and sex on lipidome variability in 104 healthy subjects. We found sebaceous lipids to constitute an abundant component of the SC lipidome as they diffuse into the topmost SC layers forming a gradient. Lipidomic variability with respect to sampling depth, site and subject is considerable, and mainly accredited to sebaceous lipids, while stratum corneum lipids vary less. This stresses the importance of sampling design and the role of sebaceous lipids in skin studies. äLarge-scale human skin lipidomics by quantitative, high-throughput sho(epmc).pdf DeepDyve Pubget Overpricing