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Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Biol+Chem 2017 ; 292 (9): 3720-8 Nephropedia Template TP
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Iso-?-acids, Bitter Components of Beer, Prevent Inflammation and Cognitive Decline Induced in a Mouse Model of Alzheimer s Disease* #MMPMID28087694
Ano Y; Dohata A; Taniguchi Y; Hoshi A; Uchida K; Takashima A; Nakayama H
J Biol Chem 2017[Mar]; 292 (9): 3720-8 PMID28087694show ga
Alongside the rapid growth in aging populations worldwide, prevention and therapy for age-related memory decline and dementia are in great demand to maintain a long, healthy life. Here we found that iso-?-acids, hop-derived bitter compounds in beer, enhance microglial phagocytosis and suppress inflammation via activation of the peroxisome proliferator-activated receptor ?. In normal mice, oral administration of iso-?-acids led to a significant increase both in CD11b and CD206 double-positive anti-inflammatory type microglia (p < 0.05) and in microglial phagocytosis in the brain. In Alzheimer's model 5xFAD mice, oral administration of iso-?-acids resulted in a 21% reduction in amyloid ? in the cerebral cortex as observed by immunohistochemical analysis, a significant reduction in inflammatory cytokines such as IL-1? and chemokines including macrophage inflammatory protein-1? in the cerebral cortex (p < 0.05) and a significant improvement in a novel object recognition test (p < 0.05), as compared with control-fed 5xFAD mice. The differences in iso-?-acid-fed mice were due to the induction of microglia to an anti-inflammatory phenotype. The present study is the first to report that amyloid ? deposition and inflammation are suppressed in a mouse model of Alzheimer's disease by a single component, iso-?-acids, via the regulation of microglial activation. The suppression of neuroinflammation and improvement in cognitive function suggests that iso-?-acids contained in beer may be useful for the prevention of dementia.