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10.1074/jbc.M116.763813 http://scihub22266oqcxt.onion/10.1074/jbc.M116.763813 C5339755!5339755 !28087694     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28087694 &cmd=llinks): Failed to open stream: HTTP request failed! 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Iso-?-acids, Bitter Components of Beer, Prevent Inflammation and Cognitive Decline Induced in a Mouse Model of Alzheimer s Disease |pdf=|usr=}}{{28087694 }} gab.com Text Iso- -acids, Bitter Components of Beer, Prevent Inflammation and Cognitive Decline Induced in a Mouse Model of Alzheimer s Disease JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=28087694 #FOAvip Alongside the rapid growth in aging populations worldwide, prevention and therapy for age-related memory decline and dementia are in great demand to maintain a long, healthy life. Here we found that iso-?-acids, hop-derived bitter compounds in beer, enhance microglial phagocytosis and suppress inflammation via activation of the peroxisome proliferator-activated receptor ?. In normal mice, oral administration of iso-?-acids led to a significant increase both in CD11b and CD206 double-positive anti-inflammatory type microglia (p < 0.05) and in microglial phagocytosis in the brain. In Alzheimer's model 5xFAD mice, oral administration of iso-?-acids resulted in a 21% reduction in amyloid ? in the cerebral cortex as observed by immunohistochemical analysis, a significant reduction in inflammatory cytokines such as IL-1? and chemokines including macrophage inflammatory protein-1? in the cerebral cortex (p < 0.05) and a significant improvement in a novel object recognition test (p < 0.05), as compared with control-fed 5xFAD mice. The differences in iso-?-acid-fed mice were due to the induction of microglia to an anti-inflammatory phenotype. The present study is the first to report that amyloid ? deposition and inflammation are suppressed in a mouse model of Alzheimer's disease by a single component, iso-?-acids, via the regulation of microglial activation. The suppression of neuroinflammation and improvement in cognitive function suggests that iso-?-acids contained in beer may be useful for the prevention of dementia. Twit Text FOAVip Iso- -acids, Bitter Components of Beer, Prevent Inflammation and Cognitive Decline Induced in a Mouse Model of Alzheimer s Disease ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=28087694 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28087694 #FOAvip English Wikipedia <ref>{{Cite pmid|28087694 }}</ref> Iso-?-acids, Bitter Components of Beer, Prevent Inflammation and Cognitive Decline Induced in a Mouse Model of Alzheimer s Disease #MMPMID28087694 Ano Y ; Dohata A ; Taniguchi Y ; Hoshi A ; Uchida K ; Takashima A ; Nakayama H J Biol Chem 2017[Mar]; 292 (9 ): 3720-3728 PMID28087694 show ga Alongside the rapid growth in aging populations worldwide, prevention and therapy for age-related memory decline and dementia are in great demand to maintain a long, healthy life. Here we found that iso-?-acids, hop-derived bitter compounds in beer, enhance microglial phagocytosis and suppress inflammation via activation of the peroxisome proliferator-activated receptor ?. In normal mice, oral administration of iso-?-acids led to a significant increase both in CD11b and CD206 double-positive anti-inflammatory type microglia (p < 0.05) and in microglial phagocytosis in the brain. In Alzheimer's model 5xFAD mice, oral administration of iso-?-acids resulted in a 21% reduction in amyloid ? in the cerebral cortex as observed by immunohistochemical analysis, a significant reduction in inflammatory cytokines such as IL-1? and chemokines including macrophage inflammatory protein-1? in the cerebral cortex (p < 0.05) and a significant improvement in a novel object recognition test (p < 0.05), as compared with control-fed 5xFAD mice. The differences in iso-?-acid-fed mice were due to the induction of microglia to an anti-inflammatory phenotype. The present study is the first to report that amyloid ? deposition and inflammation are suppressed in a mouse model of Alzheimer's disease by a single component, iso-?-acids, via the regulation of microglial activation. The suppression of neuroinflammation and improvement in cognitive function suggests that iso-?-acids contained in beer may be useful for the prevention of dementia. |*Beer [MESH] |Acids/*chemistry [MESH] |Administration, Oral [MESH] |Alzheimer Disease/genetics/*metabolism [MESH] |Amyloid beta-Peptides/metabolism [MESH] |Animals [MESH] |Anti-Inflammatory Agents/chemistry [MESH] |Blood-Brain Barrier [MESH] |CD11b Antigen/metabolism [MESH] |Cell Separation [MESH] |Cells, Cultured [MESH] |Chemokine CCL3/metabolism [MESH] |Chromatography, High Pressure Liquid [MESH] |Chromatography, Liquid [MESH] |Cognitive Dysfunction/*prevention & control [MESH] |Disease Models, Animal [MESH] |Humans [MESH] |Immunohistochemistry [MESH] |Inflammation/*prevention & control [MESH] |Lectins, C-Type/metabolism [MESH] |Mannose Receptor [MESH] |Mannose-Binding Lectins/metabolism [MESH] |Mice [MESH] |Mice, Transgenic [MESH] |Microglia/metabolism [MESH] |Phagocytosis [MESH] |Phenotype [MESH] |Receptors, Cell Surface/metabolism [MESH]Iso-?-acids, Bitter Components of Beer, Prevent Inflammation and Cogni(epmc).pdf DeepDyve Pubget Overpricing