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10.1038/srep43921 http://scihub22266oqcxt.onion/10.1038/srep43921 C5339724!5339724!28266622     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28266622|t=2017. Sorting Nexin 9 facilitates podocin endocytosis in the injured podocyte |pdf=|usr=}}{{28266622}} gab.com Text Sorting Nexin 9 facilitates podocin endocytosis in the injured podocyte JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28266622 #FOAvip The irreversibility of glomerulosclerotic changes depends on the degree of podocyte injury. We have previously demonstrated the endocytic translocation of podocin to the subcellular area in severely injured podocytes and found that this process is the primary disease trigger. Here we identified the protein sorting nexin 9 (SNX9) as a novel facilitator of podocin endocytosis in a yeast two-hybrid analysis. SNX9 is involved in clathrin-mediated endocytosis, actin rearrangement and vesicle transport regulation. Our results revealed and confirmed that SNX9 interacts with podocin exclusively through the Bin?Amphiphysin?Rvs (BAR) domain of SNX9. Immunofluorescence staining revealed the expression of SNX9 in response to podocyte adriamycin-induced injury both in vitro and in vivo. Finally, an analysis of human glomerular disease biopsy samples demonstrated strong SNX9 expression and co-localization with podocin in samples representative of severe podocyte injury, such as IgA nephropathy with poor prognosis, membranous nephropathy and focal segmental glomerulosclerosis. In conclusion, we identified SNX9 as a facilitator of podocin endocytosis in severe podocyte injury and demonstrated the expression of SNX9 in the podocytes of both nephropathy model mice and human patients with irreversible glomerular disease. Twit Text FOAVip Sorting Nexin 9 facilitates podocin endocytosis in the injured podocyte ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28266622 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28266622 #FOAvip English Wikipedia <ref>{{Cite pmid|28266622}}</ref> Sorting Nexin 9 facilitates podocin endocytosis in the injured podocyte #MMPMID28266622 Sasaki Y; Hidaka T; Ueno T; Akiba-Takagi M; Trejo JAO; Seki T; Nagai-Hosoe Y; Tanaka E; Horikoshi S; Tomino Y; Suzuki Y; Asanuma K Sci Rep 2017[]; 7 (ä): ä PMID28266622show ga The irreversibility of glomerulosclerotic changes depends on the degree of podocyte injury. We have previously demonstrated the endocytic translocation of podocin to the subcellular area in severely injured podocytes and found that this process is the primary disease trigger. Here we identified the protein sorting nexin 9 (SNX9) as a novel facilitator of podocin endocytosis in a yeast two-hybrid analysis. SNX9 is involved in clathrin-mediated endocytosis, actin rearrangement and vesicle transport regulation. Our results revealed and confirmed that SNX9 interacts with podocin exclusively through the Bin?Amphiphysin?Rvs (BAR) domain of SNX9. Immunofluorescence staining revealed the expression of SNX9 in response to podocyte adriamycin-induced injury both in vitro and in vivo. Finally, an analysis of human glomerular disease biopsy samples demonstrated strong SNX9 expression and co-localization with podocin in samples representative of severe podocyte injury, such as IgA nephropathy with poor prognosis, membranous nephropathy and focal segmental glomerulosclerosis. In conclusion, we identified SNX9 as a facilitator of podocin endocytosis in severe podocyte injury and demonstrated the expression of SNX9 in the podocytes of both nephropathy model mice and human patients with irreversible glomerular disease. äSorting Nexin 9 facilitates podocin endocytosis in the injured podocyt(epmc).pdf DeepDyve Pubget Overpricing