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10.1084/jem.20162024

http://scihub22266oqcxt.onion/10.1084/jem.20162024
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C5339682!5339682!28232471
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suck abstract from ncbi


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pmid28232471      J+Exp+Med 2017 ; 214 (3): 579-96
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  • Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer #MMPMID28232471
  • Öhlund D; Handly-Santana A; Biffi G; Elyada E; Almeida AS; Ponz-Sarvise M; Corbo V; Oni TE; Hearn SA; Lee EJ; Chio IIC; Hwang CI; Tiriac H; Baker LA; Engle DD; Feig C; Kultti A; Egeblad M; Fearon DT; Crawford JM; Clevers H; Park Y; Tuveson DA
  • J Exp Med 2017[Mar]; 214 (3): 579-96 PMID28232471show ga
  • Öhlund et al. develop a three-dimensional co-culture platform of neoplastic pancreatic ductal organoids and pancreatic stellate cells (PSCs) to characterize the dynamic crosstalk between cancer cells and stromal cells, and to address stromal heterogeneity. The co-cultures reveal the co-existence of two phenotypically distinct populations of PSCs, providing insights into PDA biology and prompting a reconsideration of interventional strategies.
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