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pmid28289614      World+J+Plast+Surg 2017 ; 6 (1): 54-61
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  • Effect of Systemic Antioxidant Allopurinol Therapy on Skin Flap Survival #MMPMID28289614
  • Rasti Ardakani M; Al-Dam A; Rashad A; Shayesteh Moghadam A
  • World J Plast Surg 2017[Jan]; 6 (1): 54-61 PMID28289614show ga
  • BACKGROUND: It has been reported that systemic administration of allopurinol improves cell survival. This study was aimed to evaluate effects of allopurinol on skin flaps in dogs. METHODS: Twenty dogs underwent one skin flap surgery with a 2-week interval. The first procedure was performed according to the standard protocols. The second phase was started by a 1-week pretreatment with allopurinol. Length of the necrotic zone was measured and recorded daily. At each phase, flaps were removed and sent for histopathological study after 1 week observation. RESULTS: Mean length of the necrotic zone in allopurinol treated skin flaps has been significantly less than normal flaps over all 7 days of observation (p<0.0001). Histopathology study showed less inflammation and more normal tissue structure in the allopurinol treated skin flaps. CONCLUSION: It was demonstrated that systemic administration of allopurinol significantly improved skin flap survival.
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