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10.2147/OTT.S126463 http://scihub22266oqcxt.onion/10.2147/OTT.S126463 C5338937!5338937!28280366     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Onco+Targets+Ther 2017 ; 10 (ä): 1317-25 Nephropedia Template TP {{tp|p=28280366|t=2017. Salinomycin repressed the epithelial?mesenchymal transition of epithelial ovarian cancer cells via downregulating Wnt/?-catenin pathway |pdf=|usr=}}{{28280366}} gab.com Text Salinomycin repressed the epithelial mesenchymal transition of epithelial ovarian cancer cells via downregulating Wnt/ -catenin pathway JO: Onco Targets Ther http://www.kidney.de/pget.php?&tw=1&pmid=28280366 #FOAvip Epithelial ovarian cancer (EOC) is the leading cause of death among all gynecological malignancies. Most patients are diagnosed in the advanced stage and have distant metastasis ultimately. Salinomycin has been demonstrated to reduce invasive capacity of multiple tumor cells. The objective of this study was to investigate the effects of salinomycin on EOC cells. The cell counting kit 8 (CCK-8) and Boyden chamber assays showed that salinomycin could effectively reduce the abilities of proliferation, migration and invasion in EOC cells. The western blot assay showed that salinomycin could increase the expression of epithelial markers (E-cadherin and Keratin) while decrease the expression of mesenchymal markers (N-cadherin and vimentin) in a dose-dependent manner. These results were ascertained by reverse transcription polymerase chain reaction (RT-PCR). Besides, salinomycin could downregulate the expression of proteins associated with the Wnt/?-catenin pathway and repress the nuclear translocation of ?-catenin. It was also shown that salinomycin could reverse the aberrant activation of the canonical Wnt pathway induced by GSK-3? inhibitor (SB216763). Our results revealed that salinomycin could inhibit the proliferation, migration and invasion in EOC cells. In addition, the inhibitive effect of salinomycin on the invasive ability was mediated by repressing the epithelial?mesenchymal transition (EMT) program, which may be achieved through its inhibition of the Wnt/?-catenin pathway. Twit Text FOAVip Salinomycin repressed the epithelial mesenchymal transition of epithelial ovarian cancer cells via downregulating Wnt/ -catenin pathway ????Onco Targets Ther http://www.kidney.de/pget.php?&tw=1&pmid=28280366 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28280366 #FOAvip English Wikipedia <ref>{{Cite pmid|28280366}}</ref> Salinomycin repressed the epithelial?mesenchymal transition of epithelial ovarian cancer cells via downregulating Wnt/?-catenin pathway #MMPMID28280366 Li R; Dong T; Hu C; Lu J; Dai J; Liu P Onco Targets Ther 2017[]; 10 (ä): 1317-25 PMID28280366show ga Epithelial ovarian cancer (EOC) is the leading cause of death among all gynecological malignancies. Most patients are diagnosed in the advanced stage and have distant metastasis ultimately. Salinomycin has been demonstrated to reduce invasive capacity of multiple tumor cells. The objective of this study was to investigate the effects of salinomycin on EOC cells. The cell counting kit 8 (CCK-8) and Boyden chamber assays showed that salinomycin could effectively reduce the abilities of proliferation, migration and invasion in EOC cells. The western blot assay showed that salinomycin could increase the expression of epithelial markers (E-cadherin and Keratin) while decrease the expression of mesenchymal markers (N-cadherin and vimentin) in a dose-dependent manner. These results were ascertained by reverse transcription polymerase chain reaction (RT-PCR). Besides, salinomycin could downregulate the expression of proteins associated with the Wnt/?-catenin pathway and repress the nuclear translocation of ?-catenin. It was also shown that salinomycin could reverse the aberrant activation of the canonical Wnt pathway induced by GSK-3? inhibitor (SB216763). Our results revealed that salinomycin could inhibit the proliferation, migration and invasion in EOC cells. In addition, the inhibitive effect of salinomycin on the invasive ability was mediated by repressing the epithelial?mesenchymal transition (EMT) program, which may be achieved through its inhibition of the Wnt/?-catenin pathway. äSalinomycin repressed the epithelial?mesenchymal transition of epithel(epmc).pdf DeepDyve Pubget Overpricing