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10.7554/eLife.22235 http://scihub22266oqcxt.onion/10.7554/eLife.22235 C5338918!5338918!28263180     free     free     free       eLife 2017 ; 6 (ä): ä Nephropedia Template TP {{tp|p=28263180|t=2017. Uncoupling apical constriction from tissue invagination |pdf=|usr=}}{{28263180}} gab.com Text Uncoupling apical constriction from tissue invagination JO: eLife http://www.kidney.de/pget.php?&tw=1&pmid=28263180 #FOAvip Apical constriction is a widely utilized cell shape change linked to folding, bending and invagination of polarized epithelia. It remains unclear how apical constriction is regulated spatiotemporally during tissue invagination and how this cellular process contributes to tube formation in different developmental contexts. Using Drosophila salivary gland (SG) invagination as a model, we show that regulation of folded gastrulation expression by the Fork head transcription factor is required for apicomedial accumulation of Rho kinase and non-muscle myosin II, which coordinate apical constriction. We demonstrate that neither loss of spatially coordinated apical constriction nor its complete blockage prevent internalization and tube formation, although such manipulations affect the geometry of invagination. When apical constriction is disrupted, compressing force generated by a tissue-level myosin cable contributes to SG invagination. We demonstrate that fully elongated polarized SGs can form outside the embryo, suggesting that tube formation and elongation are intrinsic properties of the SG.DOI:http://dx.doi.org/10.7554/eLife.22235.001 Twit Text FOAVip Uncoupling apical constriction from tissue invagination ????eLife http://www.kidney.de/pget.php?&tw=1&pmid=28263180 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28263180 #FOAvip English Wikipedia <ref>{{Cite pmid|28263180}}</ref> Uncoupling apical constriction from tissue invagination #MMPMID28263180 Chung S; Kim S; Andrew DJ eLife 2017[]; 6 (ä): ä PMID28263180show ga Apical constriction is a widely utilized cell shape change linked to folding, bending and invagination of polarized epithelia. It remains unclear how apical constriction is regulated spatiotemporally during tissue invagination and how this cellular process contributes to tube formation in different developmental contexts. Using Drosophila salivary gland (SG) invagination as a model, we show that regulation of folded gastrulation expression by the Fork head transcription factor is required for apicomedial accumulation of Rho kinase and non-muscle myosin II, which coordinate apical constriction. We demonstrate that neither loss of spatially coordinated apical constriction nor its complete blockage prevent internalization and tube formation, although such manipulations affect the geometry of invagination. When apical constriction is disrupted, compressing force generated by a tissue-level myosin cable contributes to SG invagination. We demonstrate that fully elongated polarized SGs can form outside the embryo, suggesting that tube formation and elongation are intrinsic properties of the SG.DOI:http://dx.doi.org/10.7554/eLife.22235.001 äUncoupling apical constriction from tissue invagination (epmc).pdf DeepDyve Pubget Overpricing