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10.1126/scisignal.aaf3596 http://scihub22266oqcxt.onion/10.1126/scisignal.aaf3596 C5338747!5338747 !27577261     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27577261 &cmd=llinks): Failed to open stream: HTTP request failed! 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Distinct microenvironmental cues stimulate divergent TLR4-mediated signaling pathways in macrophages |pdf=|usr=}}{{27577261 }} gab.com Text Distinct microenvironmental cues stimulate divergent TLR4-mediated signaling pathways in macrophages JO: Sci Signal http://www.kidney.de/pget.php?&tw=1&pmid=27577261 #FOAvip Macrophages exhibit a phenotypic plasticity that enables them to orchestrate specific immune responses to distinct threats. The microbial product lipopolysaccharide (LPS) and the extracellular matrix glycoprotein tenascin-C are released during bacterial infection and tissue injury, respectively, and both activate Toll-like receptor 4 (TLR4). We found that these two TLR4 ligands stimulated distinct signaling pathways in macrophages, resulting in cells with divergent phenotypes. Although macrophages activated by LPS or tenascin-C displayed some common features, including activation of nuclear factor ?B and mitogen-activated protein kinase signaling and cytokine synthesis, each ligand stimulated the production of different subsets of cytokines and generated different phosphoproteomic signatures. Moreover, tenascin-C promoted the generation of macrophages that exhibited increased synthesis and phosphorylation of extracellular matrix components, whereas LPS stimulated the production of macrophages that exhibited an enhanced capacity to degrade the matrix. These data reveal how the activation of one pattern recognition receptor by different microenvironmental cues generates macrophage with distinct phenotypes. Twit Text FOAVip Distinct microenvironmental cues stimulate divergent TLR4-mediated signaling pathways in macrophages ????Sci Signal http://www.kidney.de/pget.php?&tw=1&pmid=27577261 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27577261 #FOAvip English Wikipedia <ref>{{Cite pmid|27577261 }}</ref> Distinct microenvironmental cues stimulate divergent TLR4-mediated signaling pathways in macrophages #MMPMID27577261 Piccinini AM ; Zuliani-Alvarez L ; Lim JM ; Midwood KS Sci Signal 2016[Aug]; 9 (443 ): ra86 PMID27577261 show ga Macrophages exhibit a phenotypic plasticity that enables them to orchestrate specific immune responses to distinct threats. The microbial product lipopolysaccharide (LPS) and the extracellular matrix glycoprotein tenascin-C are released during bacterial infection and tissue injury, respectively, and both activate Toll-like receptor 4 (TLR4). We found that these two TLR4 ligands stimulated distinct signaling pathways in macrophages, resulting in cells with divergent phenotypes. Although macrophages activated by LPS or tenascin-C displayed some common features, including activation of nuclear factor ?B and mitogen-activated protein kinase signaling and cytokine synthesis, each ligand stimulated the production of different subsets of cytokines and generated different phosphoproteomic signatures. Moreover, tenascin-C promoted the generation of macrophages that exhibited increased synthesis and phosphorylation of extracellular matrix components, whereas LPS stimulated the production of macrophages that exhibited an enhanced capacity to degrade the matrix. These data reveal how the activation of one pattern recognition receptor by different microenvironmental cues generates macrophage with distinct phenotypes. |*Signal Transduction [MESH] |Cells, Cultured [MESH] |Cellular Microenvironment [MESH] |Cytokines/metabolism [MESH] |Humans [MESH] |Lipopolysaccharides/*metabolism [MESH] |Macrophages/immunology/*metabolism [MESH] |Phosphoproteins/*metabolism [MESH] |Tenascin/*metabolism [MESH]Distinct microenvironmental cues stimulate divergent TLR4-mediated sig(epmc).pdf DeepDyve Pubget Overpricing