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10.1038/onc.2016.197 http://scihub22266oqcxt.onion/10.1038/onc.2016.197 C5338638!5338638 !27292260     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27292260 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncogene 2017 ; 36 (2 ): 168-181 Nephropedia Template TP {{tp|p=27292260 |t=2017. Elevated STAT3 expression in ovarian cancer ascites promotes invasion and metastasis: a potential therapeutic target |pdf=|usr=}}{{27292260 }} gab.com Text Elevated STAT3 expression in ovarian cancer ascites promotes invasion and metastasis: a potential therapeutic target JO: Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=27292260 #FOAvip Although activation of the STAT3 pathway has been associated with tumor progression in a wide variety of cancer types (including ovarian cancer), the precise mechanism of invasion and metastasis due to STAT3 are not fully delineated in ovarian cancer. We found that pSTAT3 Tyr705 is constitutively activated in patient ascites and ascites-derived ovarian cancer cells (ADOCCs), and the range of STAT3 expression could be very high to low. In vivo transplantation of ADOCCs with high pSTAT3 expression into the ovarian bursa of mice resulted in a large primary tumor and widespread peritoneal metastases. In contrast, ADOCCs with low STAT3 expression or ADOCCs with STAT3 expression knockdown, led to reduced tumor growth and an absence of metastases in vivo. Cytokines derived from the ADOCC culture medium activate the interleukin (IL)-6/STAT pathway in the STAT3 knockout (KO) cells, compensating for the absence of inherent STAT3 in the cells. Treatment with HO-3867 (a novel STAT3 inhibitor at 100?p.p.m. in an orthotopic murine model) significantly suppressed ovarian tumor growth, angiogenesis and metastasis by targeting STAT3 and its downstream proteins. HO-3867 was found to have cytotoxic effects in ex vivo cultures of freshly collected human ovarian cancers, including those resistant to platinum-based chemotherapy. Our results show that STAT3 is necessary for ovarian tumor progression/metastasis and highlight the potential for targeting STAT3 by HO-3867 as a therapeutic strategy for ovarian cancer. Twit Text FOAVip Elevated STAT3 expression in ovarian cancer ascites promotes invasion and metastasis: a potential therapeutic target ????Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=27292260 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27292260 #FOAvip English Wikipedia <ref>{{Cite pmid|27292260 }}</ref> Elevated STAT3 expression in ovarian cancer ascites promotes invasion and metastasis: a potential therapeutic target #MMPMID27292260 Saini U ; Naidu S ; ElNaggar AC ; Bid HK ; Wallbillich JJ ; Bixel K ; Bolyard C ; Suarez AA ; Kaur B ; Kuppusamy P ; Hays J ; Goodfellow PJ ; Cohn DE ; Selvendiran K Oncogene 2017[Jan]; 36 (2 ): 168-181 PMID27292260 show ga Although activation of the STAT3 pathway has been associated with tumor progression in a wide variety of cancer types (including ovarian cancer), the precise mechanism of invasion and metastasis due to STAT3 are not fully delineated in ovarian cancer. We found that pSTAT3 Tyr705 is constitutively activated in patient ascites and ascites-derived ovarian cancer cells (ADOCCs), and the range of STAT3 expression could be very high to low. In vivo transplantation of ADOCCs with high pSTAT3 expression into the ovarian bursa of mice resulted in a large primary tumor and widespread peritoneal metastases. In contrast, ADOCCs with low STAT3 expression or ADOCCs with STAT3 expression knockdown, led to reduced tumor growth and an absence of metastases in vivo. Cytokines derived from the ADOCC culture medium activate the interleukin (IL)-6/STAT pathway in the STAT3 knockout (KO) cells, compensating for the absence of inherent STAT3 in the cells. Treatment with HO-3867 (a novel STAT3 inhibitor at 100?p.p.m. in an orthotopic murine model) significantly suppressed ovarian tumor growth, angiogenesis and metastasis by targeting STAT3 and its downstream proteins. HO-3867 was found to have cytotoxic effects in ex vivo cultures of freshly collected human ovarian cancers, including those resistant to platinum-based chemotherapy. Our results show that STAT3 is necessary for ovarian tumor progression/metastasis and highlight the potential for targeting STAT3 by HO-3867 as a therapeutic strategy for ovarian cancer. |*Up-Regulation/drug effects [MESH] |Animals [MESH] |Ascites/metabolism/*pathology [MESH] |Cell Movement [MESH] |Female [MESH] |Gene Expression Regulation, Neoplastic/drug effects [MESH] |Gene Knockout Techniques [MESH] |Humans [MESH] |Mice [MESH] |Neoplasm Invasiveness [MESH] |Neoplasm Metastasis [MESH] |Ovarian Neoplasms/drug therapy/genetics/metabolism/*pathology [MESH] |Piperidones/administration & dosage/pharmacology [MESH] |STAT3 Transcription Factor/genetics/*metabolism [MESH] |Signal Transduction/drug effects [MESH]Elevated STAT3 expression in ovarian cancer ascites promotes invasion (epmc).pdf DeepDyve Pubget Overpricing