Systems Biology of Platelet?Vessel Wall Interactions #MMPMID25480638
Chen Y; Corey SJ; Kim OV; Alber MS
Adv Exp Med Biol 2014[]; 844 (ä): 85-98 PMID25480638show ga
Platelets are small, anucleated cells that participate in primary hemostasis by forming a hemostatic plug at the site of a blood vessel?s breach, preventing blood loss. However, hemostatic events can lead to excessive thrombosis, resulting in life-threatening strokes, emboli, or infarction. Development of multi-scale models coupling processes at several scales and running predictive model simulations on powerful computer clusters can help interdisciplinary groups of researchers to suggest and test new patient-specific treatment strategies.