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2017 ; 7
(ä): 43800
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Dynamics of cancerous tissue correlates with invasiveness
#MMPMID28262796
West AV
; Wullkopf L
; Christensen A
; Leijnse N
; Tarp JM
; Mathiesen J
; Erler JT
; Oddershede LB
Sci Rep
2017[Mar]; 7
(ä): 43800
PMID28262796
show ga
Two of the classical hallmarks of cancer are uncontrolled cell division and
tissue invasion, which turn the disease into a systemic, life-threatening
condition. Although both processes are studied, a clear correlation between cell
division and motility of cancer cells has not been described previously. Here, we
experimentally characterize the dynamics of invasive and non-invasive breast
cancer tissues using human and murine model systems. The intrinsic tissue
velocities, as well as the divergence and vorticity around a dividing cell
correlate strongly with the invasive potential of the tissue, thus showing a
distinct correlation between tissue dynamics and aggressiveness. We formulate a
model which treats the tissue as a visco-elastic continuum. This model provides a
valid reproduction of the cancerous tissue dynamics, thus, biological signaling
is not needed to explain the observed tissue dynamics. The model returns the
characteristic force exerted by an invading cell and reveals a strong correlation
between force and invasiveness of breast cancer cells, thus pinpointing the
importance of mechanics for cancer invasion.