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10.1038/srep43800 http://scihub22266oqcxt.onion/10.1038/srep43800 C5338316!5338316 !28262796     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28262796 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (ä): 43800 Nephropedia Template TP {{tp|p=28262796 |t=2017. Dynamics of cancerous tissue correlates with invasiveness |pdf=|usr=}}{{28262796 }} gab.com Text Dynamics of cancerous tissue correlates with invasiveness JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28262796 #FOAvip Two of the classical hallmarks of cancer are uncontrolled cell division and tissue invasion, which turn the disease into a systemic, life-threatening condition. Although both processes are studied, a clear correlation between cell division and motility of cancer cells has not been described previously. Here, we experimentally characterize the dynamics of invasive and non-invasive breast cancer tissues using human and murine model systems. The intrinsic tissue velocities, as well as the divergence and vorticity around a dividing cell correlate strongly with the invasive potential of the tissue, thus showing a distinct correlation between tissue dynamics and aggressiveness. We formulate a model which treats the tissue as a visco-elastic continuum. This model provides a valid reproduction of the cancerous tissue dynamics, thus, biological signaling is not needed to explain the observed tissue dynamics. The model returns the characteristic force exerted by an invading cell and reveals a strong correlation between force and invasiveness of breast cancer cells, thus pinpointing the importance of mechanics for cancer invasion. Twit Text FOAVip Dynamics of cancerous tissue correlates with invasiveness ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28262796 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28262796 #FOAvip English Wikipedia <ref>{{Cite pmid|28262796 }}</ref> Dynamics of cancerous tissue correlates with invasiveness #MMPMID28262796 West AV ; Wullkopf L ; Christensen A ; Leijnse N ; Tarp JM ; Mathiesen J ; Erler JT ; Oddershede LB Sci Rep 2017[Mar]; 7 (ä): 43800 PMID28262796 show ga Two of the classical hallmarks of cancer are uncontrolled cell division and tissue invasion, which turn the disease into a systemic, life-threatening condition. Although both processes are studied, a clear correlation between cell division and motility of cancer cells has not been described previously. Here, we experimentally characterize the dynamics of invasive and non-invasive breast cancer tissues using human and murine model systems. The intrinsic tissue velocities, as well as the divergence and vorticity around a dividing cell correlate strongly with the invasive potential of the tissue, thus showing a distinct correlation between tissue dynamics and aggressiveness. We formulate a model which treats the tissue as a visco-elastic continuum. This model provides a valid reproduction of the cancerous tissue dynamics, thus, biological signaling is not needed to explain the observed tissue dynamics. The model returns the characteristic force exerted by an invading cell and reveals a strong correlation between force and invasiveness of breast cancer cells, thus pinpointing the importance of mechanics for cancer invasion. |*Algorithms [MESH] |*Cell Movement [MESH] |*Models, Biological [MESH] |Animals [MESH] |Breast Neoplasms/pathology [MESH] |Cell Line, Tumor [MESH] |Humans [MESH] |Kinetics [MESH] |MCF-7 Cells [MESH] |Mammary Neoplasms, Animal/pathology [MESH] |Mice [MESH] |Microscopy, Phase-Contrast [MESH] |Neoplasm Invasiveness [MESH]Dynamics of cancerous tissue correlates with invasiveness (epmc).pdf DeepDyve Pubget Overpricing