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10.1038/srep43844 http://scihub22266oqcxt.onion/10.1038/srep43844 C5338315!5338315!28262817     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28262817|t=2017. OM-85 is an immunomodulator of interferon-? production and inflammasome activity |pdf=|usr=}}{{28262817}} gab.com Text OM-85 is an immunomodulator of interferon- production and inflammasome activity JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28262817 #FOAvip The inflammasome?IL-1 axis and type I interferons (IFNs) have been shown to exert protective effects upon respiratory tract infections. Conversely, IL-1 has also been implicated in inflammatory airway pathologies such as asthma and chronic obstructive pulmonary disease (COPD). OM-85 is a bacterial extract with proved efficacy against COPD and recurrent respiratory tract infections, a cause of co-morbidity in asthmatic patients. We therefore asked whether OM-85 affects the above-mentioned innate immune pathways. Here we show that OM-85 induced interferon-? through the Toll-like receptor adaptors Trif and MyD88 in bone marrow-derived dendritic cells. Moreover, it exerted a dual role on IL-1 production; on the one hand, it upregulated proIL-1? and proIL-1? levels in a MyD88-dependent manner without activating the inflammasome. On the other hand, it repressed IL-1? secretion induced by alum, a well-known NLRP3 activator. In vivo, OM-85 diminished the recruitment of inflammatory cells in response to peritoneal alum challenge. Our findings therefore suggest that OM-85 favors a protective primed state, while dampening inflammasome activation in specific conditions. Taken together, these data bring new insights into the mechanisms of OM-85 action on innate immune pathways and suggest potential explanations for its efficacy in the treatment of virus-induced airway diseases. Twit Text FOAVip OM-85 is an immunomodulator of interferon- production and inflammasome activity ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28262817 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28262817 #FOAvip English Wikipedia <ref>{{Cite pmid|28262817}}</ref> OM-85 is an immunomodulator of interferon-? production and inflammasome activity #MMPMID28262817 Dang AT; Pasquali C; Ludigs K; Guarda G Sci Rep 2017[]; 7 (ä): ä PMID28262817show ga The inflammasome?IL-1 axis and type I interferons (IFNs) have been shown to exert protective effects upon respiratory tract infections. Conversely, IL-1 has also been implicated in inflammatory airway pathologies such as asthma and chronic obstructive pulmonary disease (COPD). OM-85 is a bacterial extract with proved efficacy against COPD and recurrent respiratory tract infections, a cause of co-morbidity in asthmatic patients. We therefore asked whether OM-85 affects the above-mentioned innate immune pathways. Here we show that OM-85 induced interferon-? through the Toll-like receptor adaptors Trif and MyD88 in bone marrow-derived dendritic cells. Moreover, it exerted a dual role on IL-1 production; on the one hand, it upregulated proIL-1? and proIL-1? levels in a MyD88-dependent manner without activating the inflammasome. On the other hand, it repressed IL-1? secretion induced by alum, a well-known NLRP3 activator. In vivo, OM-85 diminished the recruitment of inflammatory cells in response to peritoneal alum challenge. Our findings therefore suggest that OM-85 favors a protective primed state, while dampening inflammasome activation in specific conditions. Taken together, these data bring new insights into the mechanisms of OM-85 action on innate immune pathways and suggest potential explanations for its efficacy in the treatment of virus-induced airway diseases. äOM-85 is an immunomodulator of interferon-? production and inflammasom(epmc).pdf DeepDyve Pubget Overpricing